TY - JOUR
T1 - Early stages of Alzheimer's disease are alarming signs in injury deaths caused by traffic accidents in elderly people (>= 60 years of age)
T2 - A neuropathological study
AU - Wijesinghe, Printha
AU - Gorrie, Catherine
AU - Shankar, S. K.
AU - Chickabasaviah, Yasha T.
AU - Amaratunga, Dhammika
AU - Hulathduwa, Sanjayah
AU - Kumara, K. Sunil
AU - Samarasinghe, Kamani
AU - Suh, Yoo-Hun
AU - Steinbusch, H. W. M.
AU - De Silva, K. Ranil D.
PY - 2017
Y1 - 2017
N2 - Background: There is little information available in the literature concerning the contribution of dementia in injury deaths in elderly people (>= 60 years).Aim: This study was intended to investigate the extent of dementia-related pathologies in the brains of elderly people who died in traffic accidents or by suicide and to compare our findings with age-and sex-matched natural deaths in an elderly population.Materials and Methods: Autopsy-derived human brain samples from nine injury death victims (5 suicide and 4 traffic accidents) and nine age- and sex-matched natural death victims were screened for neurodegenerative and cerebrovascular pathologies using histopathological and immunohistochemical techniques. For the analysis, Statistical Package for the Social Sciences (SPSS) version 16.0 was used.Results: There was a greater likelihood for Alzheimer's disease (AD)-related changes in the elders who succumbed to traffic accidents (1 out of 4) compared to age- and sex-matched suicides (0 out of 5) or natural deaths (0 out of 9) as assessed by the National Institute on Aging - Alzheimer's Association guidelines. Actual burden of both neurofibrillary tangles (NFTs) and (SPs) was comparatively higher in the brains of traffic accidents, and the mean NFT counts were significantly higher in the region of entorhinal cortex (P <0.05). However, associations obtained for other dementia-related pathologies were not statistically important.Conclusion: Our findings suggest that early Alzheimer stages may be a contributing factor to injury deaths caused by traffic accidents in elderly people whereas suicidal brain neuropathologies resembled natural deaths.
AB - Background: There is little information available in the literature concerning the contribution of dementia in injury deaths in elderly people (>= 60 years).Aim: This study was intended to investigate the extent of dementia-related pathologies in the brains of elderly people who died in traffic accidents or by suicide and to compare our findings with age-and sex-matched natural deaths in an elderly population.Materials and Methods: Autopsy-derived human brain samples from nine injury death victims (5 suicide and 4 traffic accidents) and nine age- and sex-matched natural death victims were screened for neurodegenerative and cerebrovascular pathologies using histopathological and immunohistochemical techniques. For the analysis, Statistical Package for the Social Sciences (SPSS) version 16.0 was used.Results: There was a greater likelihood for Alzheimer's disease (AD)-related changes in the elders who succumbed to traffic accidents (1 out of 4) compared to age- and sex-matched suicides (0 out of 5) or natural deaths (0 out of 9) as assessed by the National Institute on Aging - Alzheimer's Association guidelines. Actual burden of both neurofibrillary tangles (NFTs) and (SPs) was comparatively higher in the brains of traffic accidents, and the mean NFT counts were significantly higher in the region of entorhinal cortex (P <0.05). However, associations obtained for other dementia-related pathologies were not statistically important.Conclusion: Our findings suggest that early Alzheimer stages may be a contributing factor to injury deaths caused by traffic accidents in elderly people whereas suicidal brain neuropathologies resembled natural deaths.
KW - Alzheimer-related pathologies
KW - immunohistochemistry
KW - injury deaths
KW - natural diseases
KW - NEUROFIBRILLARY TANGLES
KW - HUMAN BRAIN
KW - VASCULAR CONTRIBUTIONS
KW - PARAFFIN SECTIONS
KW - NEURITIC PLAQUES
KW - RISK-FACTORS
KW - LEWY BODIES
KW - DEMENTIA
KW - PATHOLOGY
KW - POPULATION
U2 - 10.4103/psychiatry.IndianJPsychiatry_102_16
DO - 10.4103/psychiatry.IndianJPsychiatry_102_16
M3 - Article
SN - 0019-5545
VL - 59
SP - 471
EP - 477
JO - Indian Journal of Psychiatry
JF - Indian Journal of Psychiatry
IS - 4
ER -