Does Sex Modify the Effect of Endovascular Treatment for Ischemic Stroke? A Subgroup Analysis of 7 Randomized Trials

Vicky Chalos*, Inger R. de Ridder, Hester F. Lingsma, Scott Brown, Robert J. van Oostenbrugge, Mayank Goyal, Bruce C. V. Campbell, Keith W. Muir, Francis Guillemin, Serge Bracard, Philip White, Antoni Davalos, Tudor G. Jovin, Michael D. Hill, Peter J. Mitchell, Andrew M. Demchuk, Jeffrey L. Saver, Wim H. van Zwam, Diederik W. J. Dippel, HERMES Collaboration

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background and Purpose- Previous studies have reported less favorable outcome and less effect of endovascular treatment (EVT) after ischemic stroke in women than in men. Our aim was to study the influence of sex on outcome and on the effect of EVT for ischemic stroke in recent randomized trials on EVT. Methods- We used data from 7 randomized controlled trials on EVT within the HERMES collaboration. The primary outcome was 90-day functional outcome (modified Rankin Scale). We compared baseline characteristics and outcomes between men and women. With ordinal logistic regression, we evaluated the association between EVT and 90-day functional outcome for men and women separately, adjusted for potential confounders. We tested for interaction between sex and EVT. Results- We included 1762 patients in the analyses, of whom 833 (47%) were women. Women were older (median, 70 versus 66 years; P

Original languageEnglish
Pages (from-to)2413-2419
Number of pages7
JournalStroke
Volume50
Issue number9
DOIs
Publication statusPublished - Sept 2019

Keywords

  • randomized controlled trial
  • sex
  • stroke
  • thrombectomy
  • INTRAARTERIAL TREATMENT
  • INTRAVENOUS ALTEPLASE
  • CLINICAL PRESENTATION
  • GENDER-DIFFERENCES
  • COLLATERAL STATUS
  • ARTERY-OCCLUSION
  • THROMBECTOMY
  • OUTCOMES
  • THROMBOLYSIS
  • ANGIOGRAPHY

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