Abstract
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content, attributed to altered reactive oxygen species (ROS) production and antioxidant capacity. For this purpose BEAS-2B, A549, and 143B cell lines were depleted from their mtDNA (rho(0)). Overall survival after irradiation was increased (p
Original language | English |
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Article number | 0182508 |
Number of pages | 13 |
Journal | PLOS ONE |
Volume | 12 |
Issue number | 8 |
DOIs | |
Publication status | Published - 3 Aug 2017 |
Keywords
- MITOCHONDRIAL-DNA
- SUPEROXIDE-DISMUTASE
- IONIZING-RADIATION
- SURVIVAL CURVES
- TUMOR RESPONSE
- CANCER CELLS
- LUNG-CANCER
- METABOLISM
- ANTIOXIDANT
- GENERATION