Differences in feedback- and inhibition-related neural activity in adult ADHD.

P. Dibbets; L. Evers; P.P.M. Hurks; N. Marchetta; J. Jolles

doi:10.1016/j.bandc.2009.01.001

Differences in feedback- and inhibition-related neural activity in adult ADHD.

P. Dibbets^*, L. Evers, P.P.M. Hurks, N. Marchetta, J. Jolles

^*Corresponding author for this work

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Abstract

The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-rela red differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD.

Original language	English
Pages (from-to)	73-83
Journal	Brain and Cognition
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/j.bandc.2009.01.001
Publication status	Published - 1 Jan 2009

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10.1016/j.bandc.2009.01.001

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title = "Differences in feedback- and inhibition-related neural activity in adult ADHD.",

abstract = "The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-rela red differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD. ",

author = "P. Dibbets and L. Evers and P.P.M. Hurks and N. Marchetta and J. Jolles",

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T1 - Differences in feedback- and inhibition-related neural activity in adult ADHD.

AU - Dibbets, P.

AU - Evers, L.

AU - Hurks, P.P.M.

AU - Marchetta, N.

AU - Jolles, J.

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AB - The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-rela red differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD.

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