Dietary Nucleotide and Nucleoside Exposure in Infancy and Atopic Dermatitis, Recurrent Wheeze and Allergic Sensitization

M.J.C. Timmermans; P.C. Dagnelie; E.H.E. Theunisz; D. Ewalds; C. Thijs; M. Mommers; I.C.W. Arts

doi:10.1097/mpg.0000000000000689

Dietary Nucleotide and Nucleoside Exposure in Infancy and Atopic Dermatitis, Recurrent Wheeze and Allergic Sensitization

M.J.C. Timmermans, P.C. Dagnelie, E.H.E. Theunisz, D. Ewalds, C. Thijs, M. Mommers, I.C.W. Arts^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis and allergic sensitization among n = 429 children. Concentrations in breast milk were established by HPLC, concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest compared to the lowest tertile of exposure ranged from 1.11-1.99 in predominantly formula-fed children, and from 0.40-0.53 in predominantly breastfed children, but were not significant. Thus we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.

Original language	English
Pages (from-to)	691-693
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	60
Issue number	5
DOIs	https://doi.org/10.1097/mpg.0000000000000689
Publication status	Published - 1 Jan 2015

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10.1097/mpg.0000000000000689

Cite this

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title = "Dietary Nucleotide and Nucleoside Exposure in Infancy and Atopic Dermatitis, Recurrent Wheeze and Allergic Sensitization",

abstract = "We hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis and allergic sensitization among n = 429 children. Concentrations in breast milk were established by HPLC, concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest compared to the lowest tertile of exposure ranged from 1.11-1.99 in predominantly formula-fed children, and from 0.40-0.53 in predominantly breastfed children, but were not significant. Thus we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.",

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AU - Timmermans, M.J.C.

AU - Dagnelie, P.C.

AU - Theunisz, E.H.E.

AU - Ewalds, D.

AU - Thijs, C.

AU - Mommers, M.

AU - Arts, I.C.W.

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N2 - We hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis and allergic sensitization among n = 429 children. Concentrations in breast milk were established by HPLC, concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest compared to the lowest tertile of exposure ranged from 1.11-1.99 in predominantly formula-fed children, and from 0.40-0.53 in predominantly breastfed children, but were not significant. Thus we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.

AB - We hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis and allergic sensitization among n = 429 children. Concentrations in breast milk were established by HPLC, concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest compared to the lowest tertile of exposure ranged from 1.11-1.99 in predominantly formula-fed children, and from 0.40-0.53 in predominantly breastfed children, but were not significant. Thus we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.

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DO - 10.1097/mpg.0000000000000689

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