Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study

Volkert Siersma; Hanne Thorsen; Per E. Holstein; Marleen Kars; Jan Apelqvist; Edward B. Jude; Alberto Piaggesi; Karel Bakker; Michael Edmonds; Alexandra Jirkovska; Didac Mauricio; Heinrich Reike; Maximilian Spraul; Luigi Uccioli; Vilma Urbancic; Kristien van Acker; Jeff van Baal; Nicolaas C. Schaper

doi:10.1016/j.jdiacomp.2017.04.008

Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study

Volkert Siersma^*, Hanne Thorsen, Per E. Holstein, Marleen Kars, Jan Apelqvist, Edward B. Jude, Alberto Piaggesi, Karel Bakker, Michael Edmonds, Alexandra Jirkovska, Didac Mauricio, Heinrich Reike, Maximilian Spraul, Luigi Uccioli, Vilma Urbancic, Kristien van Acker, Jeff van Baal, Nicolaas C. Schaper

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment.

Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics.

Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly.

Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers. (C) 2017 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1145-1151
Number of pages	7
Journal	Journal of Diabetes and Its Complications
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.jdiacomp.2017.04.008
Publication status	Published - Jul 2017

Keywords

Diabetes mellitus
Health-related quality of life
Diabetic foot ulcer
Comorbidity
Longitudinal study
PROSPECTIVE-COHORT
MEDICAL CONDITIONS
CARE
AMPUTATION
DISEASE
PEOPLE
BURDEN

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10.1016/j.jdiacomp.2017.04.008

Cite this

Siersma, V., Thorsen, H., Holstein, P. E., Kars, M., Apelqvist, J., Jude, E. B., Piaggesi, A., Bakker, K., Edmonds, M., Jirkovska, A., Mauricio, D., Reike, H., Spraul, M., Uccioli, L., Urbancic, V., van Acker, K., van Baal, J., & Schaper, N. C. (2017). Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study. Journal of Diabetes and Its Complications, 31(7), 1145-1151. https://doi.org/10.1016/j.jdiacomp.2017.04.008

@article{d4d231b2d7d04aa1b233eee413df5511,

title = "Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study",

abstract = "Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment.Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics.Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly.Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers. (C) 2017 Elsevier Inc. All rights reserved.",

keywords = "Diabetes mellitus, Health-related quality of life, Diabetic foot ulcer, Comorbidity, Longitudinal study, PROSPECTIVE-COHORT, MEDICAL CONDITIONS, CARE, AMPUTATION, DISEASE, PEOPLE, BURDEN",

author = "Volkert Siersma and Hanne Thorsen and Holstein, {Per E.} and Marleen Kars and Jan Apelqvist and Jude, {Edward B.} and Alberto Piaggesi and Karel Bakker and Michael Edmonds and Alexandra Jirkovska and Didac Mauricio and Heinrich Reike and Maximilian Spraul and Luigi Uccioli and Vilma Urbancic and {van Acker}, Kristien and {van Baal}, Jeff and Schaper, {Nicolaas C.}",

year = "2017",

month = jul,

doi = "10.1016/j.jdiacomp.2017.04.008",

language = "English",

volume = "31",

pages = "1145--1151",

journal = "Journal of Diabetes and Its Complications",

issn = "1056-8727",

publisher = "Elsevier Science",

number = "7",

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Siersma, V, Thorsen, H, Holstein, PE, Kars, M, Apelqvist, J, Jude, EB, Piaggesi, A, Bakker, K, Edmonds, M, Jirkovska, A, Mauricio, D, Reike, H, Spraul, M, Uccioli, L, Urbancic, V, van Acker, K, van Baal, J & Schaper, NC 2017, 'Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study', Journal of Diabetes and Its Complications, vol. 31, no. 7, pp. 1145-1151. https://doi.org/10.1016/j.jdiacomp.2017.04.008

Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study. / Siersma, Volkert; Thorsen, Hanne; Holstein, Per E. et al.
In: Journal of Diabetes and Its Complications, Vol. 31, No. 7, 07.2017, p. 1145-1151.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study

AU - Siersma, Volkert

AU - Thorsen, Hanne

AU - Holstein, Per E.

AU - Kars, Marleen

AU - Apelqvist, Jan

AU - Jude, Edward B.

AU - Piaggesi, Alberto

AU - Bakker, Karel

AU - Edmonds, Michael

AU - Jirkovska, Alexandra

AU - Mauricio, Didac

AU - Reike, Heinrich

AU - Spraul, Maximilian

AU - Uccioli, Luigi

AU - Urbancic, Vilma

AU - van Acker, Kristien

AU - van Baal, Jeff

AU - Schaper, Nicolaas C.

PY - 2017/7

Y1 - 2017/7

N2 - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment.Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics.Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly.Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers. (C) 2017 Elsevier Inc. All rights reserved.

AB - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment.Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics.Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly.Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers. (C) 2017 Elsevier Inc. All rights reserved.

KW - Diabetes mellitus

KW - Health-related quality of life

KW - Diabetic foot ulcer

KW - Comorbidity

KW - Longitudinal study

KW - PROSPECTIVE-COHORT

KW - MEDICAL CONDITIONS

KW - CARE

KW - AMPUTATION

KW - DISEASE

KW - PEOPLE

KW - BURDEN

U2 - 10.1016/j.jdiacomp.2017.04.008

DO - 10.1016/j.jdiacomp.2017.04.008

M3 - Article

C2 - 28457703

SN - 1056-8727

VL - 31

SP - 1145

EP - 1151

JO - Journal of Diabetes and Its Complications

JF - Journal of Diabetes and Its Complications

IS - 7

ER -