Development of screening guidelines and clinical criteria for predementia Alzheimer's disease

P.J. Visser; F.R.J. Verhey; M. Boada; R. Bullock; P.P. de Deyn; K. Elina; G. Frisoni; L. Frolich; H. Hampel; J. Jolles; R. Jones; L. Minthon; F. Nobili; M.G.M. Olde Rikkert; P.J. Ousset; E. Reynist

doi:10.1159/000135644

Development of screening guidelines and clinical criteria for predementia Alzheimer's disease

P.J. Visser^*, F.R.J. Verhey, M. Boada, R. Bullock, P.P. de Deyn, K. Elina, G. Frisoni, L. Frolich, H. Hampel, J. Jolles, R. Jones, L. Minthon, F. Nobili, M.G.M. Olde Rikkert, P.J. Ousset, E. Reynist

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.

Original language	English
Pages (from-to)	254-265
Journal	Neuroepidemiology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1159/000135644
Publication status	Published - 1 Jan 2008

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10.1159/000135644

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Visser, P. J., Verhey, F. R. J., Boada, M., Bullock, R., de Deyn, P. P., Elina, K., Frisoni, G., Frolich, L., Hampel, H., Jolles, J., Jones, R., Minthon, L., Nobili, F., Olde Rikkert, M. G. M., Ousset, P. J., & Reynist, E. (2008). Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. Neuroepidemiology, 30(4), 254-265. https://doi.org/10.1159/000135644

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abstract = "Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.",

author = "P.J. Visser and F.R.J. Verhey and M. Boada and R. Bullock and {de Deyn}, P.P. and K. Elina and G. Frisoni and L. Frolich and H. Hampel and J. Jolles and R. Jones and L. Minthon and F. Nobili and {Olde Rikkert}, M.G.M. and P.J. Ousset and E. Reynist",

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Visser, PJ , Verhey, FRJ, Boada, M, Bullock, R, de Deyn, PP, Elina, K, Frisoni, G, Frolich, L, Hampel, H, Jolles, J, Jones, R, Minthon, L, Nobili, F, Olde Rikkert, MGM, Ousset, PJ & Reynist, E 2008, 'Development of screening guidelines and clinical criteria for predementia Alzheimer's disease', Neuroepidemiology, vol. 30, no. 4, pp. 254-265. https://doi.org/10.1159/000135644

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AU - Visser, P.J.

AU - Verhey, F.R.J.

AU - Boada, M.

AU - Bullock, R.

AU - de Deyn, P.P.

AU - Elina, K.

AU - Frisoni, G.

AU - Frolich, L.

AU - Hampel, H.

AU - Jolles, J.

AU - Jones, R.

AU - Minthon, L.

AU - Nobili, F.

AU - Olde Rikkert, M.G.M.

AU - Ousset, P.J.

AU - Reynist, E.

PY - 2008/1/1

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N2 - Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.

AB - Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.

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