Development of ‘Ready to Use Kits’ for the simultaneous qualification and quantification of drugs in different matrices using Mass Spectrometry, expanded with the application of multimodal imaging techniques

This thesis presents several aspects and applications of mass spectrometry (MS) and mass spectrometry imaging (MSI) as diagnostic toolss. It describes the possibility of analyzing different sample types (solid, liquid and gas) and how these powerful tools iare used for quantification of substances, qualification of biologically relevant molecules within samples, locating molecules in tissue sections and combining MS with clinical tools to improve the outcomes of cancer patients. Techniques such as MS, MSI, Chromatography, MALDI, ESI and REIMS are addressed in this thesis.