Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

Kai Betlem; Michael P. Down; Christopher W. Foster; Shamima Akthar; K. Eersels; B. van Grinsven; T. J. Cleij; C. E. Banks; M. Peeters

doi:10.1557/adv.2017.634

Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

Kai Betlem, Michael P. Down, Christopher W. Foster, Shamima Akthar, K. Eersels, B. van Grinsven, T. J. Cleij, C. E. Banks, M. Peeters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

32 Downloads (Pure)

Abstract

We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

Original language	English
Pages (from-to)	1569-1574
Number of pages	6
Journal	MRS Advances
Volume	3
Issue number	28
DOIs	https://doi.org/10.1557/adv.2017.634
Publication status	Published - 2018

Keywords

MOLECULARLY IMPRINTED POLYMERS

Access to Document

10.1557/adv.2017.634

Full text Final published version, 230 KBLicence: Taverne

Cite this

@article{3e91def5671f4af2b7ab46f84cdc519a,

title = "Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters",

abstract = "We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.",

keywords = "MOLECULARLY IMPRINTED POLYMERS",

author = "Kai Betlem and Down, {Michael P.} and Foster, {Christopher W.} and Shamima Akthar and K. Eersels and {van Grinsven}, B. and Cleij, {T. J.} and Banks, {C. E.} and M. Peeters",

year = "2018",

doi = "10.1557/adv.2017.634",

language = "English",

volume = "3",

pages = "1569--1574",

journal = "MRS Advances",

issn = "2059-8521",

publisher = "Cambridge University Press",

number = "28",

}

TY - JOUR

T1 - Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

AU - Betlem, Kai

AU - Down, Michael P.

AU - Foster, Christopher W.

AU - Akthar, Shamima

AU - Eersels, K.

AU - van Grinsven, B.

AU - Cleij, T. J.

AU - Banks, C. E.

AU - Peeters, M.

PY - 2018

Y1 - 2018

N2 - We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

AB - We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

KW - MOLECULARLY IMPRINTED POLYMERS

U2 - 10.1557/adv.2017.634

DO - 10.1557/adv.2017.634

M3 - Article

SN - 2059-8521

VL - 3

SP - 1569

EP - 1574

JO - MRS Advances

JF - MRS Advances

IS - 28

ER -