TY - JOUR
T1 - Detectie en subtypering van het basaalcelcarcinoom met optical coherence tomografie: een prospectieve cohortstudie
AU - Sinx, K.A.E.
AU - van Loo, E.
AU - Kelleners - Smeets, N.W.J.
AU - Nelemans, P.J.
AU - Mosterd, K.
PY - 2017/10
Y1 - 2017/10
N2 - Introduction
To date, the diagnosis and subtype of basal cell carcinoma
(BCC) is verified by histopathology by means of a
skin biopsy. However, non-invasive diagnostic strategies
such as optical coherence tomography (OCT) enable
detailed examination of skin tissue architecture and may
be used to identify BCC. In this study, the diagnostic
accuracy and level of confidence in detection and subtyping
of BCC by OCT was evaluated.
Materials & methods
In this prospective observational study, OCT imaging
was used for all lesions suspected for non-melanoma
skin cancer or pre-malignancy that were biopsied to
confirm the diagnosis at our outpatient Dermatology
clinic. Decisions on treatment were guided by clinical
examination and biopsy conform standard care. The OCT
images were assessed by two investigators, blinded to the
histological diagnosis. Diagnostic accuracy and certainty
of clinical diagnosis alone was compared to the diagnostic
accuracy and certainty of the combination of clinical
diagnosis and OCT imaging, using histopathological
diagnosis of the biopsy specimen as the gold standard.
Aim of the study
The aim of the study is to investigate the diagnostic value
of OCT in addition to clinical examination for the detection
and subtyping of BCC. Diagnostic parameters such
as the sensitivity, specificity, positive- and negative predictive
value were evaluated.
AB - Introduction
To date, the diagnosis and subtype of basal cell carcinoma
(BCC) is verified by histopathology by means of a
skin biopsy. However, non-invasive diagnostic strategies
such as optical coherence tomography (OCT) enable
detailed examination of skin tissue architecture and may
be used to identify BCC. In this study, the diagnostic
accuracy and level of confidence in detection and subtyping
of BCC by OCT was evaluated.
Materials & methods
In this prospective observational study, OCT imaging
was used for all lesions suspected for non-melanoma
skin cancer or pre-malignancy that were biopsied to
confirm the diagnosis at our outpatient Dermatology
clinic. Decisions on treatment were guided by clinical
examination and biopsy conform standard care. The OCT
images were assessed by two investigators, blinded to the
histological diagnosis. Diagnostic accuracy and certainty
of clinical diagnosis alone was compared to the diagnostic
accuracy and certainty of the combination of clinical
diagnosis and OCT imaging, using histopathological
diagnosis of the biopsy specimen as the gold standard.
Aim of the study
The aim of the study is to investigate the diagnostic value
of OCT in addition to clinical examination for the detection
and subtyping of BCC. Diagnostic parameters such
as the sensitivity, specificity, positive- and negative predictive
value were evaluated.
M3 - Article
SN - 0925-8604
VL - 27
SP - 568
EP - 571
JO - Nederlands Tijdschrift voor Dermatologie en Venereologie
JF - Nederlands Tijdschrift voor Dermatologie en Venereologie
IS - 10
ER -