TY - JOUR
T1 - Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation
AU - Garn, Holger
AU - Bahn, Sabine
AU - Baune, Bernhard T.
AU - Binder, Elisabeth B.
AU - Bisgaard, Hans
AU - Chatila, Talal A.
AU - Chavakis, Triantafyllos
AU - Culmsee, Carsten
AU - Dannlowski, Udo
AU - Gay, Steffen
AU - Gern, James
AU - Haahtela, Tari
AU - Kircher, Tilo
AU - Mueller-Ladner, Ulf
AU - Neurath, Markus F.
AU - Preissner, Klaus T.
AU - Reinhardt, Christoph
AU - Rook, Graham
AU - Russell, Shannon
AU - Schmeck, Bernd
AU - Stappenbeck, Thaddeus
AU - Steinhoff, Ulrich
AU - van Os, Jim
AU - Weiss, Scott
AU - Zemlin, Michael
AU - Renz, Harald
PY - 2016/7
Y1 - 2016/7
N2 - Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.
AB - Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.
KW - Chronic inflammation
KW - immune dysregulation
KW - metabolism
KW - environment
KW - epigenetics
KW - stress
KW - biodiversity
U2 - 10.1016/j.jaci.2016.02.046
DO - 10.1016/j.jaci.2016.02.046
M3 - Article
SN - 0091-6749
VL - 138
SP - 47
EP - 56
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -