Cross-border dissemination of methicillin-resistant Staphylococcus aureus, Euregio Meuse-Rhin region

R.H.C.A. Deurenberg; E. Nulens; H. Valvatne; S. Sebastian; C. Driessen; J. Craeghs; E. De Brauwer; B. Heising; Y.J. Kraat; J. Riebe; F.S. Stals; T.A. Trienekens; J. Scheres; A.W. Friedrich; F.H. van Tiel; P.S. Beisser; E.E. Stobberingh

doi:10.3201/eid1505.071618

Cross-border dissemination of methicillin-resistant Staphylococcus aureus, Euregio Meuse-Rhin region

R.H.C.A. Deurenberg^*, E. Nulens, H. Valvatne, S. Sebastian, C. Driessen, J. Craeghs, E. De Brauwer, B. Heising, Y.J. Kraat, J. Riebe, F.S. Stals, T.A. Trienekens, J. Scheres, A.W. Friedrich, F.H. van Tiel, P.S. Beisser, E.E. Stobberingh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Because the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) differs among the 3 countries forming the Euregio Meuse-Rhin (EMR) region (Belgium, Germany, and the Netherlands), cross-border healthcare requires information about the spread of MRSA in the EMR. We investigated the emergence, dissemination, and diversity of MRSA clones in the EMR by using several typing methods. MRSA associated with clonal complexes 5, 8, 30, and 45 was disseminated throughout the EMR. Dutch isolates, mainly associated with sequence types (ST) ST5-MRSA-II, ST5-MRSA-IV, ST8-MRSA-IV, and ST45-MSRA-IV had a more diverse genetic background than the isolates from Belgium and Germany, associated with ST45-MRSA-IV and ST5-MRSA-II, respectively. MRSA associated with pigs (ST398-MRSA-IV/V) was found in the Dutch area of the EMR. Five percent of the MRSA isolates harbored Panton-Valentine leukocidin and were classified as community-associated MRSA associated with ST1, 8, 30, 80, and 89.

Original language	English
Pages (from-to)	727-734
Journal	Emerging Infectious Diseases
Volume	15
Issue number	5
DOIs	https://doi.org/10.3201/eid1505.071618
Publication status	Published - 1 Jan 2009

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10.3201/eid1505.071618Licence: CC BY

Cite this

Deurenberg, R. H. C. A., Nulens, E., Valvatne, H., Sebastian, S., Driessen, C., Craeghs, J., De Brauwer, E., Heising, B., Kraat, Y. J., Riebe, J., Stals, F. S., Trienekens, T. A., Scheres, J., Friedrich, A. W., van Tiel, F. H., Beisser, P. S., & Stobberingh, E. E. (2009). Cross-border dissemination of methicillin-resistant Staphylococcus aureus, Euregio Meuse-Rhin region. Emerging Infectious Diseases, 15(5), 727-734. https://doi.org/10.3201/eid1505.071618

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title = "Cross-border dissemination of methicillin-resistant Staphylococcus aureus, Euregio Meuse-Rhin region",

abstract = "Because the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) differs among the 3 countries forming the Euregio Meuse-Rhin (EMR) region (Belgium, Germany, and the Netherlands), cross-border healthcare requires information about the spread of MRSA in the EMR. We investigated the emergence, dissemination, and diversity of MRSA clones in the EMR by using several typing methods. MRSA associated with clonal complexes 5, 8, 30, and 45 was disseminated throughout the EMR. Dutch isolates, mainly associated with sequence types (ST) ST5-MRSA-II, ST5-MRSA-IV, ST8-MRSA-IV, and ST45-MSRA-IV had a more diverse genetic background than the isolates from Belgium and Germany, associated with ST45-MRSA-IV and ST5-MRSA-II, respectively. MRSA associated with pigs (ST398-MRSA-IV/V) was found in the Dutch area of the EMR. Five percent of the MRSA isolates harbored Panton-Valentine leukocidin and were classified as community-associated MRSA associated with ST1, 8, 30, 80, and 89.",

author = "R.H.C.A. Deurenberg and E. Nulens and H. Valvatne and S. Sebastian and C. Driessen and J. Craeghs and {De Brauwer}, E. and B. Heising and Y.J. Kraat and J. Riebe and F.S. Stals and T.A. Trienekens and J. Scheres and A.W. Friedrich and {van Tiel}, F.H. and P.S. Beisser and E.E. Stobberingh",

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Deurenberg, RHCA, Nulens, E, Valvatne, H, Sebastian, S, Driessen, C, Craeghs, J, De Brauwer, E, Heising, B, Kraat, YJ, Riebe, J, Stals, FS, Trienekens, TA, Scheres, J, Friedrich, AW, van Tiel, FH, Beisser, PS & Stobberingh, EE 2009, 'Cross-border dissemination of methicillin-resistant Staphylococcus aureus, Euregio Meuse-Rhin region', Emerging Infectious Diseases, vol. 15, no. 5, pp. 727-734. https://doi.org/10.3201/eid1505.071618

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AU - Sebastian, S.

AU - Driessen, C.

AU - Craeghs, J.

AU - De Brauwer, E.

AU - Heising, B.

AU - Kraat, Y.J.

AU - Riebe, J.

AU - Stals, F.S.

AU - Trienekens, T.A.

AU - Scheres, J.

AU - Friedrich, A.W.

AU - van Tiel, F.H.

AU - Beisser, P.S.

AU - Stobberingh, E.E.

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AB - Because the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) differs among the 3 countries forming the Euregio Meuse-Rhin (EMR) region (Belgium, Germany, and the Netherlands), cross-border healthcare requires information about the spread of MRSA in the EMR. We investigated the emergence, dissemination, and diversity of MRSA clones in the EMR by using several typing methods. MRSA associated with clonal complexes 5, 8, 30, and 45 was disseminated throughout the EMR. Dutch isolates, mainly associated with sequence types (ST) ST5-MRSA-II, ST5-MRSA-IV, ST8-MRSA-IV, and ST45-MSRA-IV had a more diverse genetic background than the isolates from Belgium and Germany, associated with ST45-MRSA-IV and ST5-MRSA-II, respectively. MRSA associated with pigs (ST398-MRSA-IV/V) was found in the Dutch area of the EMR. Five percent of the MRSA isolates harbored Panton-Valentine leukocidin and were classified as community-associated MRSA associated with ST1, 8, 30, 80, and 89.

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