Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs

Valeria Lima Passos; Frans E. S. Tan; Martijn P. F. Berger

doi:10.1016/j.csda.2010.04.030

Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs

Valeria Lima Passos^*, Frans E. S. Tan, Martijn P. F. Berger

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Customarily, the choice between one- or two-colour microarray platforms is based on their respective practical and technical merits, contingent on objectives and constraints of the study at stake. Statistical efficiency, if accounted for, plays a secondary role. A cost-efficiency comparison of the one- and two-colour designs for a 2 x 4 time course experiment was conducted. It is shown that differences in costs between the platforms' designs, once adjusted for statistical efficiency, are not always negligible. The extent of these differences is largely influenced by subjects and array prices as well as by biological and error variances in their relative magnitude. Circumstances are described, in which cost-efficiency considerations will have an added value in motivating the selection of a microarray platform at the design stage.

Original language	English
Pages (from-to)	944-954
Journal	Computational Statistics & Data Analysis
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/j.csda.2010.04.030
Publication status	Published - 1 Jan 2011

Keywords

One- and two-colour microarray designs
Microarray cost-efficiency
Time course experiment
Random intercept model
Platform comparison

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10.1016/j.csda.2010.04.030

Cite this

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abstract = "Customarily, the choice between one- or two-colour microarray platforms is based on their respective practical and technical merits, contingent on objectives and constraints of the study at stake. Statistical efficiency, if accounted for, plays a secondary role. A cost-efficiency comparison of the one- and two-colour designs for a 2 x 4 time course experiment was conducted. It is shown that differences in costs between the platforms' designs, once adjusted for statistical efficiency, are not always negligible. The extent of these differences is largely influenced by subjects and array prices as well as by biological and error variances in their relative magnitude. Circumstances are described, in which cost-efficiency considerations will have an added value in motivating the selection of a microarray platform at the design stage. ",

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AU - Berger, Martijn P. F.

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