Abstract
Background & aims
The Oligo Element Sore Trial has shown that supplementation with a disease-specific nutritional formula enriched with arginine, zinc, and antioxidants improves pressure ulcer (PU) healing in malnourished patients compared to an isocaloric–isonitrogenous support. However, the use of such a nutritional formula needs to be supported also by a cost-effectiveness evaluation.
Methods
This economic evaluation – from a local healthcare system perspective – was conducted alongside a multicenter, randomized, controlled trial following a piggy-back approach. The primary efficacy endpoint was the percentage of change in PU area at 8 weeks. The cost analysis focused on: the difference in direct medical costs of local PU care between groups and incremental cost-effectiveness ratio (ICER) of nutritional therapy related to significant study endpoints (percentage of change in PU area and ≥40% reduction in PU area at 8 weeks).
Results
Although the experimental formula was more expensive (mean difference: 39.4 Euros; P < 0.001), its use resulted in money saving with respect to both non-nutritional PU care activities (difference, −113.7 Euros; P = 0.001) and costs of local PU care (difference, −74.3 Euros; P = 0.013). Therefore, given its efficacy it proved to be a cost-effective intervention. The robustness of these results was confirmed by the sensitivity analyses.
Conclusion
The use of a disease-specific oral nutritional formula not only results in better healing of PUs, but also reduces the costs of local PU care from a local healthcare system perspective
Original language | English |
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Pages (from-to) | 246-252 |
Number of pages | 7 |
Journal | Clinical Nutrition |
Volume | 36 |
Issue number | 1 |
Early online date | 2 Dec 2015 |
DOIs | |
Publication status | Published - 1 Feb 2017 |
Keywords
- Pressure ulcers
- Oral nutritional support
- Healing
- Cost-effectiveness
- Incremental cost-effectiveness ratio
- RANDOMIZED CONTROLLED-TRIAL
- LONG-TERM-CARE
- ECONOMIC-EVALUATION
- INTERVENTION
- MALNUTRITION
- MANAGEMENT
- RESIDENTS
- ADULTS