TY - JOUR
T1 - Cortical mechanisms of spatial hearing
AU - van der Heijden, Kiki
AU - Rauschecker, Josef P
AU - de Gelder, Beatrice
AU - Formisano, Elia
N1 - Funding Information:
The work of K.v.d.H. is partially supported by the Erasmus Mundus Auditory Cognitive Neuroscience Network. The work of E.F. is partially supported by The Netherlands Organization for Scientific Research (VICI grant number 453–12–002) and the Dutch Province of Limburg (Maastricht Centre for Systems Biology). The work of J.P.R. is partially supported by the US National Science Foundation (PIRE grant number OISE-0730255), the US National Institutes of Health (grant numbers R01EY018923 and R01DC014989) and the Technische Universität München Institute for Advanced Study, funded by the German Excellence Initiative and the European Union Seventh Framework Programme (grant number 291763). The work of B.d.G. is partially supported by the European Union Seventh Framework Programme (grant number 295673) and the European Union’s Horizon 2020 Research and Innovation Programme (grant number 645553).
Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/10
Y1 - 2019/10
N2 - Humans and other animals use spatial hearing to rapidly localize events in the environment. However, neural encoding of sound location is a complex process involving the computation and integration of multiple spatial cues that are not represented directly in the sensory organ (the cochlea). Our understanding of these mechanisms has increased enormously in the past few years. Current research is focused on the contribution of animal models for understanding human spatial audition, the effects of behavioural demands on neural sound location encoding, the emergence of a cue-independent location representation in the auditory cortex, and the relationship between single-source and concurrent location encoding in complex auditory scenes. Furthermore, computational modelling seeks to unravel how neural representations of sound source locations are derived from the complex binaural waveforms of real-life sounds. In this article, we review and integrate the latest insights from neurophysiological, neuroimaging and computational modelling studies of mammalian spatial hearing. We propose that the cortical representation of sound location emerges from recurrent processing taking place in a dynamic, adaptive network of early (primary) and higher-order (posterior-dorsal and dorsolateral prefrontal) auditory regions. This cortical network accommodates changing behavioural requirements and is especially relevant for processing the location of real-life, complex sounds and complex auditory scenes.
AB - Humans and other animals use spatial hearing to rapidly localize events in the environment. However, neural encoding of sound location is a complex process involving the computation and integration of multiple spatial cues that are not represented directly in the sensory organ (the cochlea). Our understanding of these mechanisms has increased enormously in the past few years. Current research is focused on the contribution of animal models for understanding human spatial audition, the effects of behavioural demands on neural sound location encoding, the emergence of a cue-independent location representation in the auditory cortex, and the relationship between single-source and concurrent location encoding in complex auditory scenes. Furthermore, computational modelling seeks to unravel how neural representations of sound source locations are derived from the complex binaural waveforms of real-life sounds. In this article, we review and integrate the latest insights from neurophysiological, neuroimaging and computational modelling studies of mammalian spatial hearing. We propose that the cortical representation of sound location emerges from recurrent processing taking place in a dynamic, adaptive network of early (primary) and higher-order (posterior-dorsal and dorsolateral prefrontal) auditory regions. This cortical network accommodates changing behavioural requirements and is especially relevant for processing the location of real-life, complex sounds and complex auditory scenes.
KW - PRIMARY AUDITORY-CORTEX
KW - INTERAURAL TIME DIFFERENCES
KW - SUPERIOR OLIVARY COMPLEX
KW - SOUND-SOURCE LOCATION
KW - STREAM SEGREGATION
KW - RECEPTIVE-FIELDS
KW - BINAURAL CUES
KW - BRAIN-STEM
KW - OBJECT REPRESENTATIONS
KW - POPULATION ACTIVITY
U2 - 10.1038/s41583-019-0206-5
DO - 10.1038/s41583-019-0206-5
M3 - (Systematic) Review article
C2 - 31467450
SN - 1471-003X
VL - 20
SP - 609
EP - 623
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 10
ER -