COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

Dorien H. Nieman; Sara Dragt; Esther D. A. van Duin; Nadine Denneman; Jozefien M. Overbeek; Lieuwe de Haan; Judith Rietdijk; Helga K. Ising; Rianne M. C. Klaassen; Therese van Amelsvoort; Lex Wunderink; Mark van der Gaag; Don H. Linszen

doi:10.1016/j.schres.2016.03.015

COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

Dorien H. Nieman^*, Sara Dragt, Esther D. A. van Duin, Nadine Denneman, Jozefien M. Overbeek, Lieuwe de Haan, Judith Rietdijk, Helga K. Ising, Rianne M. C. Klaassen, Therese van Amelsvoort, Lex Wunderink, Mark van der Gaag, Don H. Linszen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Methods: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Results: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Conclusions: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.

Original language	English
Pages (from-to)	24-28
Journal	Schizophrenia Research
Volume	174
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2016.03.015
Publication status	Published - Jul 2016

Keywords

Psychosis
At Risk Mental State
COMT Val(158)Met
Cannabis
GxE interaction

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10.1016/j.schres.2016.03.015

Cite this

Nieman, D. H., Dragt, S., van Duin, E. D. A., Denneman, N., Overbeek, J. M., de Haan, L., Rietdijk, J., Ising, H. K., Klaassen, R. M. C., van Amelsvoort, T., Wunderink, L., van der Gaag, M., & Linszen, D. H. (2016). COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions. Schizophrenia Research, 174(1-3), 24-28. https://doi.org/10.1016/j.schres.2016.03.015

@article{de78b9e4b9974305b8e2f0babcca44bf,

title = "COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions",

abstract = "Background: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Methods: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Results: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Conclusions: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms. ",

keywords = "Psychosis, At Risk Mental State, COMT Val(158)Met, Cannabis, GxE interaction",

author = "Nieman, {Dorien H.} and Sara Dragt and {van Duin}, {Esther D. A.} and Nadine Denneman and Overbeek, {Jozefien M.} and {de Haan}, Lieuwe and Judith Rietdijk and Ising, {Helga K.} and Klaassen, {Rianne M. C.} and {van Amelsvoort}, Therese and Lex Wunderink and {van der Gaag}, Mark and Linszen, {Don H.}",

year = "2016",

month = jul,

doi = "10.1016/j.schres.2016.03.015",

language = "English",

volume = "174",

pages = "24--28",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier Science",

number = "1-3",

}

Nieman, DH, Dragt, S, van Duin, EDA, Denneman, N, Overbeek, JM, de Haan, L, Rietdijk, J, Ising, HK, Klaassen, RMC, van Amelsvoort, T, Wunderink, L, van der Gaag, M & Linszen, DH 2016, 'COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions', Schizophrenia Research, vol. 174, no. 1-3, pp. 24-28. https://doi.org/10.1016/j.schres.2016.03.015

TY - JOUR

T1 - COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

AU - Nieman, Dorien H.

AU - Dragt, Sara

AU - van Duin, Esther D. A.

AU - Denneman, Nadine

AU - Overbeek, Jozefien M.

AU - de Haan, Lieuwe

AU - Rietdijk, Judith

AU - Ising, Helga K.

AU - Klaassen, Rianne M. C.

AU - van Amelsvoort, Therese

AU - Wunderink, Lex

AU - van der Gaag, Mark

AU - Linszen, Don H.

PY - 2016/7

Y1 - 2016/7

N2 - Background: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Methods: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Results: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Conclusions: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.

AB - Background: Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Methods: Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Results: Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Conclusions: Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.

KW - Psychosis

KW - At Risk Mental State

KW - COMT Val(158)Met

KW - Cannabis

KW - GxE interaction

U2 - 10.1016/j.schres.2016.03.015

DO - 10.1016/j.schres.2016.03.015

M3 - Article

C2 - 27052366

SN - 0920-9964

VL - 174

SP - 24

EP - 28

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -