Abstract
Purpose: To compare pretreatment scans with perfusion computed tomography (pCT) vs. dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal tumors. Methods and Materials: Nineteen patients diagnosed with rectal cancer were included in this prospective study. All patients underwent both pCT and DCE-MRI. Imaging was performed on a dedicated 40-slice CT positron emission tomography system and a 3-T MRI system. Dynamic contrast enhancement was measured in tumor tissue and the external iliac artery. Tumor perfusion was quantified in terms of pharmacokinetic parameters: transfer constant K-trans, fractional extravascular extracellular space nu(e), and fractional plasma volume nu(p). Pharmacokinetic parameter values and their heterogeneity (by 80% quantile value) were compared between pCT and DCE-MRI. Results: Tumor K-trans values correlated significantly for the voxel-by-voxel derived median (Kendall's tau correlation, tau = 0.81, p
Original language | English |
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Pages (from-to) | 400-408 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 77 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Jun 2010 |
Keywords
- Perfusion CT
- DCE-MRI
- Pharmacokinetic model
- Rectal cancer
- Tumor perfusion