Cognitive Phenotypes in Parkinson's Disease Differ in Terms of Brain-Network Organization and Connectivity

Renaud Lopes; Christine Delmaire; Luc Defebvre; Anja J. Moonen; Annelien A. Duits; Paul Hofman; Albert F. G. Leentjens; Kathy Dujardin

doi:10.1002/hbm.23474

Cognitive Phenotypes in Parkinson's Disease Differ in Terms of Brain-Network Organization and Connectivity

Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J. Moonen, Annelien A. Duits, Paul Hofman, Albert F. G. Leentjens, Kathy Dujardin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole- brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4- 5). RsfMRI whole- brain connectivity was examined by two complementary approaches: graph theory for studying network functional organization and network- based statistics (NBS) for exploring functional connectivity amongst brain regions. After adjustment for age, duration of formal education and center of acquisition, there were significant group differences for all functional organization indexes: functional organization decreased (G1> G2> G3> G4- 5) as cognitive impairment worsened. Between- group differences in functional connectivity (NBS corrected, P<0.01) mainly concerned the ventral prefrontal, parietal, temporal and occipital cortices as well as the basal ganglia. In Parkinson's disease, brain network organization is progressively disrupted as cognitive impairment worsens, with an increasing number of altered connections between brain regions. We observed reduced connectivity in highly associative areas, even in patients with only slight mental slowing. The association of slowed mental processing with loss of connectivity between highly associative areas could be an early marker of cognitive impairment in Parkinson's disease and may contribute to the detection of prodromal forms of Parkinson's disease dementia. (C) 2016 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	1604-1621
Number of pages	18
Journal	Human Brain Mapping
Volume	38
Issue number	3
DOIs	https://doi.org/10.1002/hbm.23474
Publication status	Published - Mar 2017

Keywords

cognition
dementia
fMRI
resting state connectivity
DEFAULT-MODE NETWORK
FUNCTIONAL CONNECTIVITY
RESTING-STATE
RATING-SCALE
DEMENTIA
DISORDERS
APATHY
VALIDATION
IMPAIRMENT
FREQUENCY

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title = "Cognitive Phenotypes in Parkinson's Disease Differ in Terms of Brain-Network Organization and Connectivity",

abstract = "Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole- brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4- 5). RsfMRI whole- brain connectivity was examined by two complementary approaches: graph theory for studying network functional organization and network- based statistics (NBS) for exploring functional connectivity amongst brain regions. After adjustment for age, duration of formal education and center of acquisition, there were significant group differences for all functional organization indexes: functional organization decreased (G1> G2> G3> G4- 5) as cognitive impairment worsened. Between- group differences in functional connectivity (NBS corrected, P<0.01) mainly concerned the ventral prefrontal, parietal, temporal and occipital cortices as well as the basal ganglia. In Parkinson's disease, brain network organization is progressively disrupted as cognitive impairment worsens, with an increasing number of altered connections between brain regions. We observed reduced connectivity in highly associative areas, even in patients with only slight mental slowing. The association of slowed mental processing with loss of connectivity between highly associative areas could be an early marker of cognitive impairment in Parkinson's disease and may contribute to the detection of prodromal forms of Parkinson's disease dementia. (C) 2016 Wiley Periodicals, Inc.",

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author = "Renaud Lopes and Christine Delmaire and Luc Defebvre and Moonen, {Anja J.} and Duits, {Annelien A.} and Paul Hofman and Leentjens, {Albert F. G.} and Kathy Dujardin",

year = "2017",

month = mar,

doi = "10.1002/hbm.23474",

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AU - Lopes, Renaud

AU - Delmaire, Christine

AU - Defebvre, Luc

AU - Moonen, Anja J.

AU - Duits, Annelien A.

AU - Hofman, Paul

AU - Leentjens, Albert F. G.

AU - Dujardin, Kathy

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N2 - Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole- brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4- 5). RsfMRI whole- brain connectivity was examined by two complementary approaches: graph theory for studying network functional organization and network- based statistics (NBS) for exploring functional connectivity amongst brain regions. After adjustment for age, duration of formal education and center of acquisition, there were significant group differences for all functional organization indexes: functional organization decreased (G1> G2> G3> G4- 5) as cognitive impairment worsened. Between- group differences in functional connectivity (NBS corrected, P<0.01) mainly concerned the ventral prefrontal, parietal, temporal and occipital cortices as well as the basal ganglia. In Parkinson's disease, brain network organization is progressively disrupted as cognitive impairment worsens, with an increasing number of altered connections between brain regions. We observed reduced connectivity in highly associative areas, even in patients with only slight mental slowing. The association of slowed mental processing with loss of connectivity between highly associative areas could be an early marker of cognitive impairment in Parkinson's disease and may contribute to the detection of prodromal forms of Parkinson's disease dementia. (C) 2016 Wiley Periodicals, Inc.

AB - Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole- brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4- 5). RsfMRI whole- brain connectivity was examined by two complementary approaches: graph theory for studying network functional organization and network- based statistics (NBS) for exploring functional connectivity amongst brain regions. After adjustment for age, duration of formal education and center of acquisition, there were significant group differences for all functional organization indexes: functional organization decreased (G1> G2> G3> G4- 5) as cognitive impairment worsened. Between- group differences in functional connectivity (NBS corrected, P<0.01) mainly concerned the ventral prefrontal, parietal, temporal and occipital cortices as well as the basal ganglia. In Parkinson's disease, brain network organization is progressively disrupted as cognitive impairment worsens, with an increasing number of altered connections between brain regions. We observed reduced connectivity in highly associative areas, even in patients with only slight mental slowing. The association of slowed mental processing with loss of connectivity between highly associative areas could be an early marker of cognitive impairment in Parkinson's disease and may contribute to the detection of prodromal forms of Parkinson's disease dementia. (C) 2016 Wiley Periodicals, Inc.

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KW - dementia

KW - fMRI

KW - resting state connectivity

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KW - FUNCTIONAL CONNECTIVITY

KW - RESTING-STATE

KW - RATING-SCALE

KW - DEMENTIA

KW - DISORDERS

KW - APATHY

KW - VALIDATION

KW - IMPAIRMENT

KW - FREQUENCY

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DO - 10.1002/hbm.23474

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SN - 1065-9471

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JO - Human Brain Mapping

JF - Human Brain Mapping

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