TY - JOUR
T1 - Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction
AU - Strik, J.J.M.H.
AU - Honig, A.
AU - Klinkenberg, E.L.
AU - Dijkstra, J.
AU - Jolles, J.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Background: As depression is a considerable risk factor for an unfa- University of Maastricht, The Netherlands vourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue. Objective: The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression. Methods: Cognitive performance of 54 depressed patients post first-MI treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test. Results: The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance. Conclusion: In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.
AB - Background: As depression is a considerable risk factor for an unfa- University of Maastricht, The Netherlands vourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue. Objective: The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression. Methods: Cognitive performance of 54 depressed patients post first-MI treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test. Results: The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance. Conclusion: In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.
U2 - 10.1111/j.0924-2708.2006.00110.x
DO - 10.1111/j.0924-2708.2006.00110.x
M3 - Article
C2 - 26991975
SN - 0924-2708
VL - 18
SP - 1
EP - 2007
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
ER -