Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank

F.A.H.M. Cleutjens; M.A. Spruit; R.W.H.M. Ponds; J.B. Dijkstra; F.M.E. Franssen; E.F.M. Wouters; D.J.A. Janssen

doi:10.1016/j.jamda.2013.12.007

Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank

F.A.H.M. Cleutjens^*, M.A. Spruit, R.W.H.M. Ponds, J.B. Dijkstra, F.M.E. Franssen, E.F.M. Wouters, D.J.A. Janssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. DESIGN: An observational population-based study. SETTING: This research was conducted using the United Kingdom Biobank Resource. PARTICIPANTS: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. MEASUREMENTS: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. RESULTS: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [beta = -0.15 (-0.22 to -0.09)], visuospatial memory [beta round 1 = 0.06 (0.030.10)]; beta round 2 = 0.09 (<0.0010.18)), numeric short-term memory [beta = 0.05 (0.10 to <0.001)] and cognitive processing speed [beta = 4.62 (1.258.01)] after correction for possible confounders. Impairment in prospective memory [beta = 0.004 (<0.0010.01)] and numeric short-term memory [beta = 0.01 (0.0030.01)] were weakly related to FEV1 (adjusted P < .05). CONCLUSIONS: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment.

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	Journal of the American Medical Directors Association
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.jamda.2013.12.007
Publication status	Published - Mar 2014

Keywords

COPD
cognition
lung function
neuropsychological functioning
self-management
UK Biobank
PROSPECTIVE MEMORY DEFICITS
PULMONARY-DISEASE
FLUID INTELLIGENCE
WORKING-MEMORY
COPD PATIENTS
SHORT-TERM
IMPAIRMENT
PERFORMANCE
DYSFUNCTION
ABILITIES

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10.1016/j.jamda.2013.12.007

Cite this

@article{7a0ad2ef5ac44992a216a85ee0410eea,

title = "Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank",

abstract = "OBJECTIVES: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. DESIGN: An observational population-based study. SETTING: This research was conducted using the United Kingdom Biobank Resource. PARTICIPANTS: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. MEASUREMENTS: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. RESULTS: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [beta = -0.15 (-0.22 to -0.09)], visuospatial memory [beta round 1 = 0.06 (0.030.10)]; beta round 2 = 0.09 (<0.0010.18)), numeric short-term memory [beta = 0.05 (0.10 to <0.001)] and cognitive processing speed [beta = 4.62 (1.258.01)] after correction for possible confounders. Impairment in prospective memory [beta = 0.004 (<0.0010.01)] and numeric short-term memory [beta = 0.01 (0.0030.01)] were weakly related to FEV1 (adjusted P < .05). CONCLUSIONS: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment.",

keywords = "COPD, cognition, lung function, neuropsychological functioning, self-management, UK Biobank, PROSPECTIVE MEMORY DEFICITS, PULMONARY-DISEASE, FLUID INTELLIGENCE, WORKING-MEMORY, COPD PATIENTS, SHORT-TERM, IMPAIRMENT, PERFORMANCE, DYSFUNCTION, ABILITIES",

author = "F.A.H.M. Cleutjens and M.A. Spruit and R.W.H.M. Ponds and J.B. Dijkstra and F.M.E. Franssen and E.F.M. Wouters and D.J.A. Janssen",

year = "2014",

month = mar,

doi = "10.1016/j.jamda.2013.12.007",

language = "English",

volume = "15",

pages = "214--219",

journal = "Journal of the American Medical Directors Association",

issn = "1525-8610",

publisher = "Elsevier Science",

number = "3",

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TY - JOUR

T1 - Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank

AU - Cleutjens, F.A.H.M.

AU - Spruit, M.A.

AU - Ponds, R.W.H.M.

AU - Dijkstra, J.B.

AU - Franssen, F.M.E.

AU - Wouters, E.F.M.

AU - Janssen, D.J.A.

PY - 2014/3

Y1 - 2014/3

N2 - OBJECTIVES: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. DESIGN: An observational population-based study. SETTING: This research was conducted using the United Kingdom Biobank Resource. PARTICIPANTS: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. MEASUREMENTS: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. RESULTS: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [beta = -0.15 (-0.22 to -0.09)], visuospatial memory [beta round 1 = 0.06 (0.030.10)]; beta round 2 = 0.09 (<0.0010.18)), numeric short-term memory [beta = 0.05 (0.10 to <0.001)] and cognitive processing speed [beta = 4.62 (1.258.01)] after correction for possible confounders. Impairment in prospective memory [beta = 0.004 (<0.0010.01)] and numeric short-term memory [beta = 0.01 (0.0030.01)] were weakly related to FEV1 (adjusted P < .05). CONCLUSIONS: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment.

AB - OBJECTIVES: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. DESIGN: An observational population-based study. SETTING: This research was conducted using the United Kingdom Biobank Resource. PARTICIPANTS: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. MEASUREMENTS: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. RESULTS: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [beta = -0.15 (-0.22 to -0.09)], visuospatial memory [beta round 1 = 0.06 (0.030.10)]; beta round 2 = 0.09 (<0.0010.18)), numeric short-term memory [beta = 0.05 (0.10 to <0.001)] and cognitive processing speed [beta = 4.62 (1.258.01)] after correction for possible confounders. Impairment in prospective memory [beta = 0.004 (<0.0010.01)] and numeric short-term memory [beta = 0.01 (0.0030.01)] were weakly related to FEV1 (adjusted P < .05). CONCLUSIONS: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment.

KW - COPD

KW - cognition

KW - lung function

KW - neuropsychological functioning

KW - self-management

KW - UK Biobank

KW - PROSPECTIVE MEMORY DEFICITS

KW - PULMONARY-DISEASE

KW - FLUID INTELLIGENCE

KW - WORKING-MEMORY

KW - COPD PATIENTS

KW - SHORT-TERM

KW - IMPAIRMENT

KW - PERFORMANCE

KW - DYSFUNCTION

KW - ABILITIES

U2 - 10.1016/j.jamda.2013.12.007

DO - 10.1016/j.jamda.2013.12.007

M3 - Article

SN - 1525-8610

VL - 15

SP - 214

EP - 219

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

IS - 3

ER -