TY - JOUR
T1 - Clinical and Histological Prognostic Factors for Local Recurrence and Metastasis of Cutaneous Squamous Cell Carcinoma: Analysis of a Defined Population
AU - Roozeboom, Marieke H.
AU - Lohman, Bjorn G. P. M.
AU - Westers-Attema, Annet
AU - Nelemans, Patty J.
AU - Botter-Weck, Anita A.
AU - van Marion, Arienne M. W.
AU - Kelleners-Smeets, Nicole W. J.
PY - 2013
Y1 - 2013
N2 - Cutaneous squamous cell carcinomas (cSCC) can recur locally and can metastasize. The objective of this study was to identify clinical and histopathological prognostic factors for local recurrence and metastasis in cSCCs at any body site. Clinical and histopathological data were collected from 224 patients with cSCC. During the median follow-up period of 43 months (range 0-73 months) the cumulative probabilities of recurrence-free survival at 1, 2 and 4 years post-treatment were 98.0%, 96.9% and 94.7%, respectively, and for metastasis-free survival 98.1%, 97.0% and 95.9%, respectively. In univariate survival analyses, significant predictors for local recurrence were tumour diameter and tumour thickness. For metastasis this was invasion of deeper structures, location on the ear, poor differentiation, tumour diameter and tumour thickness. In multivariate survival analysis, every millimetre increase in both tumour diameter and tumour thickness were independent predictors for local recurrence as well as for metastasis and, therefore, it is important to report these in patients' files. Defining prognostic variables is important for diagnostic workup, treatment and follow-up for an individual patient.
AB - Cutaneous squamous cell carcinomas (cSCC) can recur locally and can metastasize. The objective of this study was to identify clinical and histopathological prognostic factors for local recurrence and metastasis in cSCCs at any body site. Clinical and histopathological data were collected from 224 patients with cSCC. During the median follow-up period of 43 months (range 0-73 months) the cumulative probabilities of recurrence-free survival at 1, 2 and 4 years post-treatment were 98.0%, 96.9% and 94.7%, respectively, and for metastasis-free survival 98.1%, 97.0% and 95.9%, respectively. In univariate survival analyses, significant predictors for local recurrence were tumour diameter and tumour thickness. For metastasis this was invasion of deeper structures, location on the ear, poor differentiation, tumour diameter and tumour thickness. In multivariate survival analysis, every millimetre increase in both tumour diameter and tumour thickness were independent predictors for local recurrence as well as for metastasis and, therefore, it is important to report these in patients' files. Defining prognostic variables is important for diagnostic workup, treatment and follow-up for an individual patient.
KW - skin cancer
KW - risk factors
U2 - 10.2340/00015555-1501
DO - 10.2340/00015555-1501
M3 - Article
C2 - 23138613
SN - 0001-5555
VL - 93
SP - 417
EP - 421
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 4
ER -