TY - JOUR
T1 - Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies
AU - Wanders, Anne J.
AU - Alssema, Marjan
AU - De Hoon, Sabine E. M.
AU - Feskens, Edith J. M.
AU - van Woudenbergh, Geertruida J.
AU - van der Kallen, Carla J.
AU - Zock, Peter L.
AU - Refsum, Helga
AU - Drevon, Christian A.
AU - Elshorbagy, Amany
AU - Schalkwijk, Casper G.
AU - Stehouwer, Coen D. A.
AU - Dekker, Jacqueline M.
AU - van Greevenbroek, Marleen M. J.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (mu g/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA beta = 0.28, ALA beta = 0.13, EPA beta = 0.34, and DHA beta = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA beta = 0.19, ALA beta = 0.10, EPA beta = 0.31, and DHA beta = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA. (C) 2018 S. Karger AG, Basel
AB - Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (mu g/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA beta = 0.28, ALA beta = 0.13, EPA beta = 0.34, and DHA beta = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA beta = 0.19, ALA beta = 0.10, EPA beta = 0.31, and DHA beta = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA. (C) 2018 S. Karger AG, Basel
KW - Dietary fat
KW - Circulating fatty acids
KW - Biomarker
KW - Polyunsaturated fat
KW - ALPHA-LINOLENIC ACID
KW - FOOD FREQUENCY QUESTIONNAIRE
KW - DOCOSAHEXAENOIC ACID
KW - ENERGY-INTAKE
KW - LIFE-STYLE
KW - EICOSAPENTAENOIC ACID
KW - ADIPOSE-TISSUE
KW - HUMANS
KW - LIMITATIONS
KW - CONVERSION
U2 - 10.1159/000486244
DO - 10.1159/000486244
M3 - Article
C2 - 29393106
SN - 0250-6807
VL - 72
SP - 117
EP - 125
JO - Annals of Nutrition and Metabolism
JF - Annals of Nutrition and Metabolism
IS - 2
ER -