Abstract
Selecting the right partner faster: in protein chemoselective conjugation, the use of levulinic acid for ketone introduction leads to slow oxime formation and poor yield because of internal cyclization, especially at low concentrations. A mechanism for cyclization is proposed and alternative keto-acids have been tested. These showed faster formation of oximes without side products.
Original language | English |
---|---|
Pages (from-to) | 2431-2434 |
Journal | Chembiochem |
Volume | 14 |
Issue number | 18 |
DOIs | |
Publication status | Published - 16 Dec 2013 |
Keywords
- bioconjugation
- ketones
- oximes
- peptides
- RANTES