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Cannabis and tolerance: acute drug impairment as a function of cannabis use history

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Cannabis and tolerance : acute drug impairment as a function of cannabis use history. / Ramaekers, J G; van Wel, J H; Spronk, D B; Toennes, S W; Kuypers, K P C; Theunissen, E L; Verkes, R J.

In: Scientific Reports, Vol. 6, 26843, 26.05.2016.

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@article{78581eea81e84f71bdf8e91fa04153cf,
title = "Cannabis and tolerance: acute drug impairment as a function of cannabis use history",
abstract = "Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic.",
keywords = "SMOKED MARIJUANA, ORAL DELTA(9)-TETRAHYDROCANNABINOL, PSYCHOMOTOR PERFORMANCE, THC INTOXICATION, MOTOR CONTROL, HEAVY, FREQUENT, MARIHUANA, RESPONSES, COCAINE",
author = "Ramaekers, {J G} and {van Wel}, {J H} and Spronk, {D B} and Toennes, {S W} and Kuypers, {K P C} and Theunissen, {E L} and Verkes, {R J}",
year = "2016",
month = "5",
day = "26",
doi = "10.1038/srep26843",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Cannabis and tolerance

T2 - Scientific Reports

AU - Ramaekers, J G

AU - van Wel, J H

AU - Spronk, D B

AU - Toennes, S W

AU - Kuypers, K P C

AU - Theunissen, E L

AU - Verkes, R J

PY - 2016/5/26

Y1 - 2016/5/26

N2 - Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic.

AB - Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 μg/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic.

KW - SMOKED MARIJUANA

KW - ORAL DELTA(9)-TETRAHYDROCANNABINOL

KW - PSYCHOMOTOR PERFORMANCE

KW - THC INTOXICATION

KW - MOTOR CONTROL

KW - HEAVY

KW - FREQUENT

KW - MARIHUANA

KW - RESPONSES

KW - COCAINE

U2 - 10.1038/srep26843

DO - 10.1038/srep26843

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 26843

ER -