Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?

Manouk L. E. Hendrix; Judith A. P. Bons; Roy R. G. Snellings; Otto Bekers; Sander M. J. van Kuijk; Marc E. A. Spaanderman; Salwan Al-Nasiry

doi:10.1159/000499580

Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?

Manouk L. E. Hendrix^*, Judith A. P. Bons, Roy R. G. Snellings, Otto Bekers, Sander M. J. van Kuijk, Marc E. A. Spaanderman, Salwan Al-Nasiry

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and Objectives: The aim of this study was to evaluate the value of adding fetal growth velocity and first trimester maternal biomarkers to baseline screening, for the prediction of small-for-gestational age (SGA) and adverse neonatal outcomes. Method: A retrospective cohort study was conducted of singleton pregnancies in the Maastricht University Medical Centre between 2012 and 2016. The biomarkers PAPP-A, beta-hCG, PlGF, and sFlt-1 were measured at 11-13 weeks of gestational age (GA) and two fetal growth scans were performed (18-22 and 30-34 weeks of GA). Differences in biomarkers and growth velocities were compared between appropriate-for-gestational age (AGA; birth weight percentile 10-90) and SGA (birth weight percentile

Original language	English
Pages (from-to)	274-284
Number of pages	11
Journal	Fetal Diagnosis and Therapy
Volume	46
Issue number	4
DOIs	https://doi.org/10.1159/000499580
Publication status	Published - Oct 2019

Keywords

Biochemical markers
Fetal biometry
Fetal growth restriction
Placenta
UTERINE ARTERY DOPPLER
PLASMA-PROTEIN-A
ANGIOGENIC FACTORS
TYROSINE KINASE-1
SPIRAL ARTERIES
EARLY-PREGNANCY
3RD TRIMESTER
PREECLAMPSIA
RESTRICTION
RISK

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10.1159/000499580Licence: CC BY-NC-ND

Cite this

@article{8a1afe81971b4ad69796b4bdc9dc48de,

title = "Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?",

abstract = "Background and Objectives: The aim of this study was to evaluate the value of adding fetal growth velocity and first trimester maternal biomarkers to baseline screening, for the prediction of small-for-gestational age (SGA) and adverse neonatal outcomes. Method: A retrospective cohort study was conducted of singleton pregnancies in the Maastricht University Medical Centre between 2012 and 2016. The biomarkers PAPP-A, beta-hCG, PlGF, and sFlt-1 were measured at 11-13 weeks of gestational age (GA) and two fetal growth scans were performed (18-22 and 30-34 weeks of GA). Differences in biomarkers and growth velocities were compared between appropriate-for-gestational age (AGA; birth weight percentile 10-90) and SGA (birth weight percentile",

keywords = "Biochemical markers, Fetal biometry, Fetal growth restriction, Placenta, UTERINE ARTERY DOPPLER, PLASMA-PROTEIN-A, ANGIOGENIC FACTORS, TYROSINE KINASE-1, SPIRAL ARTERIES, EARLY-PREGNANCY, 3RD TRIMESTER, PREECLAMPSIA, RESTRICTION, RISK",

author = "Hendrix, {Manouk L. E.} and Bons, {Judith A. P.} and Snellings, {Roy R. G.} and Otto Bekers and {van Kuijk}, {Sander M. J.} and Spaanderman, {Marc E. A.} and Salwan Al-Nasiry",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s) Published by S. Karger AG, Basel.",

year = "2019",

month = oct,

doi = "10.1159/000499580",

language = "English",

volume = "46",

pages = "274--284",

journal = "Fetal Diagnosis and Therapy",

issn = "1015-3837",

publisher = "Karger",

number = "4",