TY - JOUR
T1 - Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
AU - Timmers, S.
AU - Konings, E.
AU - Bilet, L.
AU - Houtkooper, R.H.
AU - van de Weijer, T.
AU - Goossens, G.H.
AU - Hoeks, J.
AU - van der Krieken, S.
AU - Ryu, D.
AU - Kersten, S.
AU - Kornips, C.F.P.
AU - Hesselink, M.K.C.
AU - Kunz, I.
AU - Schrauwen-Hinderling, V.
AU - Blaak, E.E.
AU - Auwerx, J.
AU - Schrauwen, P.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
AB - Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
U2 - 10.1016/j.cmet.2011.10.002
DO - 10.1016/j.cmet.2011.10.002
M3 - Article
C2 - 22055504
SN - 1550-4131
VL - 14
SP - 612
EP - 622
JO - Cell Metabolism
JF - Cell Metabolism
IS - 5
ER -