Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

Kong Y. Chen; Aaron M. Cypess; Maren R. Laughlin; Carol R. Haft; Houchun Harry Hu; Miriam A. Bredella; Sven Enerback; Paul E. Kinahan; Wouter van Marken Lichtenbelt; Frank I. Lin; John J. Sunderland; Kirsi A. Virtanen; Richard L. Wahl

doi:10.1016/j.cmet.2016.07.014

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

Kong Y. Chen^*, Aaron M. Cypess^*, Maren R. Laughlin^*, Carol R. Haft, Houchun Harry Hu, Miriam A. Bredella, Sven Enerback, Paul E. Kinahan, Wouter van Marken Lichtenbelt, Frank I. Lin, John J. Sunderland, Kirsi A. Virtanen, Richard L. Wahl

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.

Original language	English
Pages (from-to)	210-222
Journal	Cell Metabolism
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2016.07.014
Publication status	Published - 9 Aug 2016

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Chen, K. Y., Cypess, A. M., Laughlin, M. R., Haft, C. R., Hu, H. H., Bredella, M. A., Enerback, S., Kinahan, P. E., van Marken Lichtenbelt, W., Lin, F. I., Sunderland, J. J., Virtanen, K. A., & Wahl, R. L. (2016). Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans. Cell Metabolism, 24(2), 210-222. https://doi.org/10.1016/j.cmet.2016.07.014

@article{b0e9cdec9666472d9fb29f7dfbcdd2ca,

title = "Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans",

abstract = "Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.",

author = "Chen, {Kong Y.} and Cypess, {Aaron M.} and Laughlin, {Maren R.} and Haft, {Carol R.} and Hu, {Houchun Harry} and Bredella, {Miriam A.} and Sven Enerback and Kinahan, {Paul E.} and {van Marken Lichtenbelt}, Wouter and Lin, {Frank I.} and Sunderland, {John J.} and Virtanen, {Kirsi A.} and Wahl, {Richard L.}",

year = "2016",

month = aug,

day = "9",

doi = "10.1016/j.cmet.2016.07.014",

language = "English",

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pages = "210--222",

journal = "Cell Metabolism",

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Chen, KY, Cypess, AM, Laughlin, MR, Haft, CR, Hu, HH, Bredella, MA, Enerback, S, Kinahan, PE, van Marken Lichtenbelt, W, Lin, FI, Sunderland, JJ, Virtanen, KA & Wahl, RL 2016, 'Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans', Cell Metabolism, vol. 24, no. 2, pp. 210-222. https://doi.org/10.1016/j.cmet.2016.07.014

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AU - Cypess, Aaron M.

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AU - Haft, Carol R.

AU - Hu, Houchun Harry

AU - Bredella, Miriam A.

AU - Enerback, Sven

AU - Kinahan, Paul E.

AU - van Marken Lichtenbelt, Wouter

AU - Lin, Frank I.

AU - Sunderland, John J.

AU - Virtanen, Kirsi A.

AU - Wahl, Richard L.

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AB - Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.

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