Blood pressure variability in individuals with and without (pre)diabetes: the Maastricht Study
Research output: Contribution to journal › Article › Academic › peer-review
- CARIM - Vascular complications of diabetes and the metabolic syndrome
- Promovendi CARIM
- Interne Geneeskunde
- CARIM - Cardiovascular system dynamics
- Biomedische Technologie
- HV - Pieken Maastricht Studie
- MHeNs - Cognitive Neuropsychiatry and Clinical Neuroscience
- CAPHRI - Inequity, Participation and Globalisation
- Sociale Geneeskunde
- CARIM - Hypertension and target organ damage
- CAPHRI - Creating Value-Based Health Care
- BC - Endocrinologie
- CAPHRI - Optimising Patient Care
- BC - Interne Geneeskunde
with (incident) CVD. Therefore, we investigated the association between (pre)diabetes and very short-term to mid-term BPV, that is within-visit, 24-h and 7-day BPV.
Methods: Cross-sectional data from The Maastricht Study [normal glucose metabolism (NGM), n¼1924; prediabetes, n¼511; type 2 diabetes mellitus (T2DM), n¼975; 51%
men, aged 608 years]. We determined SD for within visit BPV (n¼3244), average real variability for 24-h BPV (n¼2699) day (0900–2100 h) and night (0100–0600 h) separately, and SD for 7-day BPV (n¼2259). Differences in
BPV as compared with NGM were assessed by multiple linear regressions with adjustment for potential confounders.
Results: In T2DM, the average systolic/diastolic values of within-visit, 24-h and 7-day BPV were 4.8/2.6, 10.5/7.3 and 10.4/6.5 mmHg, respectively, and in prediabetes 4.9/ 2.6, 10.3/7.0 and 9.4/5.9 mmHg, respectively. T2DM was associated with greater nocturnal systolic BPV [0.42mmHg (95% confidence interval: 0.05–0.80)], and greater 7-day
systolic [0.76mmHg (0.32–1.19)] and diastolic BPV [0.65mmHg (0.29–1.01)], whereas prediabetes was associated with greater within-visit systolic BPV only [0.35mmHg (0.06–0.65)], as compared with NGM.
Conclusion: Both T2DM and prediabetes are associated with slightly greater very short-term to mid-term BPV, which may, according to previous literature, explain a small part of the increased CVD risk seen in (pre)diabetes.
Nevertheless, these findings do not detract from the fact that very short-term to mid-term BPV is substantial and important in individuals with and without (pre)diabetes.
- average real variability, blood pressure variability, cardiovascular diseases, diabetes mellitus, prediabetic state, TO-VISIT VARIABILITY, AMERICAN-HEART-ASSOCIATION, OBSTRUCTIVE SLEEP-APNEA, DIABETES-MELLITUS, PROGNOSTIC-SIGNIFICANCE, BAROREFLEX SENSITIVITY, ARTERIAL STIFFNESS, EUROPEAN-SOCIETY, ALL-CAUSE, HYPERTENSION