Blimp1 regulates the transition of neonatal to adult intestinal epithelium

V. Muncan; J. Heijmans; S.D. Krasinski; N.V. Buller; M.E. Wildenberg; S. Meisner; M. Radonjic; K.A. Stapleton; W.H. Lamers; I. Biemond; M.A. van den Bergh-Weerman; D. O'Carroll; J. C. Hardwick; D.W. Hommes; G.R. van den Brink

doi:10.1038/ncomms1463

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

V. Muncan, J. Heijmans, S.D. Krasinski, N.V. Buller, M.E. Wildenberg, S. Meisner, M. Radonjic, K.A. Stapleton, W.H. Lamers, I. Biemond, M.A. van den Bergh-Weerman, D. O'Carroll, J. C. Hardwick, D.W. Hommes, G.R. van den Brink^*

^*Corresponding author for this work

Anatomie & Embryologie

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Abstract

In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.

Original language	English
Pages (from-to)	452
Journal	Nature Communications
Volume	2
DOIs	https://doi.org/10.1038/ncomms1463
Publication status	Published - 1 Jan 2011

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Muncan, V., Heijmans, J., Krasinski, S. D., Buller, N. V., Wildenberg, M. E., Meisner, S., Radonjic, M., Stapleton, K. A., Lamers, W. H., Biemond, I., van den Bergh-Weerman, M. A., O'Carroll, D., Hardwick, J. C., Hommes, D. W., & van den Brink, G. R. (2011). Blimp1 regulates the transition of neonatal to adult intestinal epithelium. Nature Communications, 2, 452. https://doi.org/10.1038/ncomms1463

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abstract = "In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.",

author = "V. Muncan and J. Heijmans and S.D. Krasinski and N.V. Buller and M.E. Wildenberg and S. Meisner and M. Radonjic and K.A. Stapleton and W.H. Lamers and I. Biemond and {van den Bergh-Weerman}, M.A. and D. O'Carroll and Hardwick, {J. C.} and D.W. Hommes and {van den Brink}, G.R.",

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Muncan, V, Heijmans, J, Krasinski, SD, Buller, NV, Wildenberg, ME, Meisner, S, Radonjic, M, Stapleton, KA, Lamers, WH, Biemond, I, van den Bergh-Weerman, MA, O'Carroll, D, Hardwick, JC, Hommes, DW & van den Brink, GR 2011, 'Blimp1 regulates the transition of neonatal to adult intestinal epithelium', Nature Communications, vol. 2, pp. 452. https://doi.org/10.1038/ncomms1463

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