TY - JOUR
T1 - Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults
AU - Duvivier, Bernard M. F. M.
AU - Schaper, Nicolaas C.
AU - Koster, Annemarie
AU - van Kan, Linh
AU - Peters, Harry P. F.
AU - Adam, Jos J.
AU - Giesbrecht, Timo
AU - Kornips, Esther
AU - Hulsbosch, Martine
AU - Willems, Paul
AU - Hesselink, Matthijs K. C.
AU - Schrauwen, Patrick
AU - Savelberg, Hans H. C. M.
PY - 2017/6/8
Y1 - 2017/6/8
N2 - Background : We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/ obese adults.Methods : In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweight/ obese participants (64 +/- 7 years, BMI 29 +/- 2 kg/m(2)) followed two activity regimens of each 4 days in free-living conditions: "Sit": sitting 13.5 h/day, standing 1.4 h/day, self-perceived light-intensity walking 0.7 h/day; for "SitLess" these activities lasted 7.6, 4.0, and 4.3 h/day, respectively. Meals were standardized and physical activity was assessed by accelerometry (activPAL). Insulin sensitivity (expressed as Matsuda-index based on an oral glucose tolerance test), circulating lipids, blood pressure, mood (pleasantness and arousal), and cognition were assessed on the morning after the activity regimens. Quality of life and sleep were assessed on the last day of the activity regimens.Results : We observed that AUC (0-190 min) for insulin decreased by 20% after SitLess vs. Sit [10,125 (656) vs. 12,633 (818); p = 0.006]. Insulin sensitivity improved by 16% after SitLess vs. Sit [Matsuda-index, mean (SEM): 6.45 (0.25) vs. 5.58 (0.25) respectively; p = 0.007]. Fasting triglycerides, non-HDL-cholesterol, and apolipoprotein B decreased by 32, 7, and 4% respectively, whereas HDL-cholesterol increased by 7% after SitLess vs. Sit (all p <0.01). Diastolic blood pressure was lower after SitLess vs. Sit (p <0.05). Pleasantness (as one marker of mood status) after the oral glucose tolerance test was higher after SitLess vs. Sit (p <0.05). There was no significant difference between regimens for cognition, quality of life and sleep.Conclusions : Reducing sitting time in free-living conditions markedly improved insulin sensitivity, circulating lipids, and diastolic blood pressure. Substituting sitting with standing and self-perceived light walking is an effective strategy to improve cardiometabolic risk factors in overweight/obese subjects.
AB - Background : We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/ obese adults.Methods : In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweight/ obese participants (64 +/- 7 years, BMI 29 +/- 2 kg/m(2)) followed two activity regimens of each 4 days in free-living conditions: "Sit": sitting 13.5 h/day, standing 1.4 h/day, self-perceived light-intensity walking 0.7 h/day; for "SitLess" these activities lasted 7.6, 4.0, and 4.3 h/day, respectively. Meals were standardized and physical activity was assessed by accelerometry (activPAL). Insulin sensitivity (expressed as Matsuda-index based on an oral glucose tolerance test), circulating lipids, blood pressure, mood (pleasantness and arousal), and cognition were assessed on the morning after the activity regimens. Quality of life and sleep were assessed on the last day of the activity regimens.Results : We observed that AUC (0-190 min) for insulin decreased by 20% after SitLess vs. Sit [10,125 (656) vs. 12,633 (818); p = 0.006]. Insulin sensitivity improved by 16% after SitLess vs. Sit [Matsuda-index, mean (SEM): 6.45 (0.25) vs. 5.58 (0.25) respectively; p = 0.007]. Fasting triglycerides, non-HDL-cholesterol, and apolipoprotein B decreased by 32, 7, and 4% respectively, whereas HDL-cholesterol increased by 7% after SitLess vs. Sit (all p <0.01). Diastolic blood pressure was lower after SitLess vs. Sit (p <0.05). Pleasantness (as one marker of mood status) after the oral glucose tolerance test was higher after SitLess vs. Sit (p <0.05). There was no significant difference between regimens for cognition, quality of life and sleep.Conclusions : Reducing sitting time in free-living conditions markedly improved insulin sensitivity, circulating lipids, and diastolic blood pressure. Substituting sitting with standing and self-perceived light walking is an effective strategy to improve cardiometabolic risk factors in overweight/obese subjects.
KW - exercise
KW - insulin sensitivity
KW - light-intensity physical activity
KW - lipids
KW - sedentary behavior
KW - sitting
KW - standing
KW - walking
KW - DENSITY-LIPOPROTEIN CHOLESTEROL
KW - HUMAN SKELETAL-MUSCLE
KW - INSULIN SENSITIVITY
KW - AEROBIC EXERCISE
KW - SEDENTARY TIME
KW - POSTPRANDIAL GLYCEMIA
KW - RANDOMIZED CROSSOVER
KW - ACTIVITY MONITOR
KW - OBESITY
KW - BREAKING
U2 - 10.3389/fphys.2017.00353
DO - 10.3389/fphys.2017.00353
M3 - Article
C2 - 28642713
SN - 1664-042X
VL - 8
JO - Frontiers in physiology
JF - Frontiers in physiology
M1 - 353
ER -