Baroreflex function is reduced in Alzheimer's disease: a candidate biomarker?

Aisha S. S. Meel-van den Abeelen; Joep Lagro; Erik D. Gommer; Jos P. H. Reulen; Jurgen A. H. R. Claassen

doi:10.1016/j.neurobiolaging.2012.10.010

Baroreflex function is reduced in Alzheimer's disease: a candidate biomarker?

Aisha S. S. Meel-van den Abeelen, Joep Lagro, Erik D. Gommer, Jos P. H. Reulen, Jurgen A. H. R. Claassen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The baroreflex (BR) reflects autonomic blood pressure control. Alzheimer's disease (AD) affects the autonomic system. Detailed properties of BR in AD are unknown. We hypothesized that BR is reduced in AD, and is influenced by autonomic effects of cholinesterase inhibitors (ChEI). BR was determined in 18 AD patients, 11 patients with mild cognitive impairment (MCI) and 19 healthy control subjects. In AD, BR was measured again after ChEI treatment. Receiver operating characteristic analysis was used to define a BR cutoff value, which was then tested in an independent validation sample of 16 AD, 18 MCI, and 18 control subjects. BR was lower in AD compared with MCI (p <0.05) and in MCI compared with healthy control subjects (p <0.01). Receiver operating characteristic analysis between AD and healthy control subjects yielded a sensitivity of 89% and a specificity of 94%. ChEI treatment increased BR with 66% (p <0.01). BR was reduced in AD and increased after treatment with ChEI. BR might be a good biomarker to further explore the link between cardiovascular disease and AD.

Original language	English
Pages (from-to)	1170-1176
Journal	Neurobiology of Aging
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2012.10.010
Publication status	Published - Apr 2013

Keywords

Baroreflex
Alzheimer's disease
Diagnostics
Dementia
Mild cognitive impairment
Autonomic nervous system
Causal model

Access to Document

10.1016/j.neurobiolaging.2012.10.010Licence: Free access - publisher

Cite this

@article{dbeaeb7ea8a144ca866913564c7fa4ee,

title = "Baroreflex function is reduced in Alzheimer's disease: a candidate biomarker?",

abstract = "The baroreflex (BR) reflects autonomic blood pressure control. Alzheimer's disease (AD) affects the autonomic system. Detailed properties of BR in AD are unknown. We hypothesized that BR is reduced in AD, and is influenced by autonomic effects of cholinesterase inhibitors (ChEI). BR was determined in 18 AD patients, 11 patients with mild cognitive impairment (MCI) and 19 healthy control subjects. In AD, BR was measured again after ChEI treatment. Receiver operating characteristic analysis was used to define a BR cutoff value, which was then tested in an independent validation sample of 16 AD, 18 MCI, and 18 control subjects. BR was lower in AD compared with MCI (p <0.05) and in MCI compared with healthy control subjects (p <0.01). Receiver operating characteristic analysis between AD and healthy control subjects yielded a sensitivity of 89% and a specificity of 94%. ChEI treatment increased BR with 66% (p <0.01). BR was reduced in AD and increased after treatment with ChEI. BR might be a good biomarker to further explore the link between cardiovascular disease and AD. ",

keywords = "Baroreflex, Alzheimer's disease, Diagnostics, Dementia, Mild cognitive impairment, Autonomic nervous system, Causal model",

author = "{Meel-van den Abeelen}, {Aisha S. S.} and Joep Lagro and Gommer, {Erik D.} and Reulen, {Jos P. H.} and Claassen, {Jurgen A. H. R.}",

year = "2013",

month = apr,

doi = "10.1016/j.neurobiolaging.2012.10.010",

language = "English",

volume = "34",

pages = "1170--1176",

journal = "Neurobiology of Aging",

issn = "0197-4580",