Baeyer-Villiger monooxygenases (BVMOs) as entry to lactones and their polyesters
Research output: Contribution to conference › Abstract › Academic
The activity of a spectrum of BVMOs on various cyclic ketones was screened in order to broaden the range of lactones as precursors for polyesters that can be synthesized by biocatalysis. Activity of the biocatalysts was measured using a spectrophotometric screening method based on nicotinamide co-factor consumption during the oxidation reaction. Combinations of ketones and BVMOs displaying activity were further investigated to analyze the structure of the oxidation products. Finally, some ketones were selected for upscaling of the biocatalyzed production of lactones at the gram scale using BVMOs.