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Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study

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Abstract

AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.

    Research areas

  • Growth factors, mucosal advancement flap, platelet-rich plasma, COMPLEX ANAL FISTULAS, FIBRIN GLUE, TRANSSPHINCTERIC FISTULAS, REPAIR, GEL, SMOKING, BONE, SURGERY, REGENERATION, GRAFTS
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Details

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalColorectal Disease
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 2011