@article{6f1f28694c7e42adb9b85b22370aa88e,
title = "Autoimmunity in psychotic disorders.: Where we stand, challenges and opportunities",
abstract = "Psychotic disorders are debilitating mental illnesses associated with abnormalities in various neurotransmitter systems. The development of disease-modifing therapies has been hampered by the mostly unknown etiologies and pathophysiologies.Autoantibodies against several neuronal antigens are responsible for autoimmune encephalitis. These auto antibodies disrupt neurotransmission within the brain, resulting in a wide range of psychiatric and neurologic manifestations, including psychosis. The overlap of symptoms of autoimmune encephalitis with psychotic disorders raised the question as to whether autoantibodies against a number of receptors, ion channel and associated proteins could ultimately be responsible for some forms of psychosis. Here we review our current knowledge, on antibody mediated autoimmunity in psychotic disorders, the different diagnostic methods and their limitations, as well as on varying therapeutic approaches targeting the immune system.",
keywords = "Channelopathies, Psychosis, Neuropsychiatric, Autoantibodies, Immunotherapy, D-ASPARTATE RECEPTOR, ANTIBODY-ASSOCIATED ENCEPHALOPATHY, NEUROLOGICAL SOFT SIGNS, NMDA-RECEPTOR, LIMBIC ENCEPHALITIS, MYASTHENIA-GRAVIS, GABA(A) RECEPTOR, CASE SERIES, ANTINEURONAL AUTOANTIBODIES, PSYCHIATRIC PRESENTATION",
author = "Marina Mane-Damas and Carolin Hoffmann and Shenghua Zong and Amanda Tan and Molenaar, {Peter C.} and Mario Losen and Pilar Martinez-Martinez",
note = "Funding Information: This work was supported by the Netherlands Organization for Scientific Research (NWO) ?Graduate School of Translational Neuroscience Program? (022005019), the Brain Foundation of the Netherlands (KS2012(1)-157) and the ZonMW NWO Program Translationeel onderzoek (40-41200-98-9257); as well as the Veni Fellowship of NWO (916.10.148), a fellowship of the Brain Foundation of the Netherlands (FS2008(1)-28), the Prinses Beatrix Spierfonds (Project WAR08-12) and the China Scholarship Council (201507720015). We would also like to thank Ms. Tanya Mohile for providing language and writing assistance. Funding Information: This work was supported by the Netherlands Organization for Scientific Research (NWO) “Graduate School of Translational Neuroscience Program” ( 022005019 ), the Brain Foundation of the Netherlands ( KS2012(1)-157 ) and the ZonMW NWO Program Translationeel onderzoek ( 40-41200-98-9257 ); as well as the Veni Fellowship of NWO ( 916.10.148 ), a fellowship of the Brain Foundation of the Netherlands ( FS2008(1)-28 ), the Prinses Beatrix Spierfonds (Project WAR08-12) and the China Scholarship Council ( 201507720015 ). Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = sep,
doi = "10.1016/j.autrev.2019.102348",
language = "English",
volume = "18",
pages = "1--14",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier Science",
number = "9",
}