Autoimmunity in psychotic disorders. Where we stand, challenges and opportunities

Marina Mane-Damas, Carolin Hoffmann, Shenghua Zong, Amanda Tan, Peter C. Molenaar, Mario Losen, Pilar Martinez-Martinez*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Psychotic disorders are debilitating mental illnesses associated with abnormalities in various neurotransmitter systems. The development of disease-modifing therapies has been hampered by the mostly unknown etiologies and pathophysiologies.

Autoantibodies against several neuronal antigens are responsible for autoimmune encephalitis. These auto antibodies disrupt neurotransmission within the brain, resulting in a wide range of psychiatric and neurologic manifestations, including psychosis. The overlap of symptoms of autoimmune encephalitis with psychotic disorders raised the question as to whether autoantibodies against a number of receptors, ion channel and associated proteins could ultimately be responsible for some forms of psychosis. Here we review our current knowledge, on antibody mediated autoimmunity in psychotic disorders, the different diagnostic methods and their limitations, as well as on varying therapeutic approaches targeting the immune system.

Original languageEnglish
Article number102348
Pages (from-to)1-14
Number of pages14
JournalAutoimmunity Reviews
Volume18
Issue number9
DOIs
Publication statusPublished - Sept 2019

Keywords

  • Channelopathies
  • Psychosis
  • Neuropsychiatric
  • Autoantibodies
  • Immunotherapy
  • D-ASPARTATE RECEPTOR
  • ANTIBODY-ASSOCIATED ENCEPHALOPATHY
  • NEUROLOGICAL SOFT SIGNS
  • NMDA-RECEPTOR
  • LIMBIC ENCEPHALITIS
  • MYASTHENIA-GRAVIS
  • GABA(A) RECEPTOR
  • CASE SERIES
  • ANTINEURONAL AUTOANTIBODIES
  • PSYCHIATRIC PRESENTATION

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