Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations

P.R. Huntjens; John Walmsley; V. Wu; Tammo Delhaas; L. Axel; Joost Lumens

doi:10.1007/978-3-319-20309-6_5

Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations

P.R. Huntjens^*, John Walmsley, V. Wu, Tammo Delhaas, L. Axel, Joost Lumens

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Septal Flash (SF) is a rapid leftward – rightward motion of the septal wall during the isovolumic contraction phase that is frequently but not always observed in heart failure patients with left bundle branch block (LBBB). The goal of the present study is to evaluate the feasibility of detecting SF by assessing septal curvature both in patients with LBBB using MRI and in simulations using the CircAdapt model of the heart and circulation. In both patients and simulations, SF was characterized by a decrease of septal wall curvature and septum to lateral wall distance, followed by a rapid increase prior to aortic valve opening. Additionally, computer simulations revealed that SF can be explained by an intra-left ventricular (septal-to-lateral wall) activation delay. Reducing contractility in the left ventricular free wall abolished the rightward SF motion in LBBB. This finding suggests that lack of SF may indicate co-morbidities that can result in non-response to cardiac resynchronization therapy.

Original language	English
Title of host publication	Functional Imaging and Modeling of the Heart. FIMH 2015
Editors	H. van Assen, P. Bovendeerd, T. Delhaas
Publisher	Springer, Cham
Pages	40-47
ISBN (Electronic)	978-3-319-20309-6
ISBN (Print)	978-3-319-20308-9
DOIs	https://doi.org/10.1007/978-3-319-20309-6_5
Publication status	Published - 2015

Publication series

Series	Lecture Notes in Computer Science
Volume	9126
ISSN	0302-9743

Access to Document

10.1007/978-3-319-20309-6_5

Cite this

Huntjens, P. R., Walmsley, J., Wu, V., Delhaas, T., Axel, L., & Lumens, J. (2015). Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations. In H. van Assen, P. Bovendeerd, & T. Delhaas (Eds.), Functional Imaging and Modeling of the Heart. FIMH 2015 (pp. 40-47). Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_5

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abstract = "Septal Flash (SF) is a rapid leftward – rightward motion of the septal wall during the isovolumic contraction phase that is frequently but not always observed in heart failure patients with left bundle branch block (LBBB). The goal of the present study is to evaluate the feasibility of detecting SF by assessing septal curvature both in patients with LBBB using MRI and in simulations using the CircAdapt model of the heart and circulation. In both patients and simulations, SF was characterized by a decrease of septal wall curvature and septum to lateral wall distance, followed by a rapid increase prior to aortic valve opening. Additionally, computer simulations revealed that SF can be explained by an intra-left ventricular (septal-to-lateral wall) activation delay. Reducing contractility in the left ventricular free wall abolished the rightward SF motion in LBBB. This finding suggests that lack of SF may indicate co-morbidities that can result in non-response to cardiac resynchronization therapy.",

author = "P.R. Huntjens and John Walmsley and V. Wu and Tammo Delhaas and L. Axel and Joost Lumens",

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Huntjens, PR, Walmsley, J, Wu, V, Delhaas, T, Axel, L & Lumens, J 2015, Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations. in H van Assen, P Bovendeerd & T Delhaas (eds), Functional Imaging and Modeling of the Heart. FIMH 2015. Springer, Cham, Lecture Notes in Computer Science, vol. 9126, pp. 40-47. https://doi.org/10.1007/978-3-319-20309-6_5

Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations. / Huntjens, P.R.; Walmsley, John; Wu, V. et al.
Functional Imaging and Modeling of the Heart. FIMH 2015. ed. / H. van Assen; P. Bovendeerd; T. Delhaas. Springer, Cham, 2015. p. 40-47 (Lecture Notes in Computer Science, Vol. 9126).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

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AB - Septal Flash (SF) is a rapid leftward – rightward motion of the septal wall during the isovolumic contraction phase that is frequently but not always observed in heart failure patients with left bundle branch block (LBBB). The goal of the present study is to evaluate the feasibility of detecting SF by assessing septal curvature both in patients with LBBB using MRI and in simulations using the CircAdapt model of the heart and circulation. In both patients and simulations, SF was characterized by a decrease of septal wall curvature and septum to lateral wall distance, followed by a rapid increase prior to aortic valve opening. Additionally, computer simulations revealed that SF can be explained by an intra-left ventricular (septal-to-lateral wall) activation delay. Reducing contractility in the left ventricular free wall abolished the rightward SF motion in LBBB. This finding suggests that lack of SF may indicate co-morbidities that can result in non-response to cardiac resynchronization therapy.

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Huntjens PR, Walmsley J, Wu V, Delhaas T, Axel L, Lumens J. Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations. In van Assen H, Bovendeerd P, Delhaas T, editors, Functional Imaging and Modeling of the Heart. FIMH 2015. Springer, Cham. 2015. p. 40-47. (Lecture Notes in Computer Science, Vol. 9126). doi: 10.1007/978-3-319-20309-6_5