Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique

M. van Onna; D.F. ten Cate; K.L. Tsoi; A.J. Meier; J.W. Jacobs; A.A. Westgeest; P.B. Meijer; M.C. van Beek; W.H. Rensen; J.W. Bijlsma

doi:10.1136/annrheumdis-2015-207315

Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique

M. van Onna^*, D.F. ten Cate, K.L. Tsoi, A.J. Meier, J.W. Jacobs, A.A. Westgeest, P.B. Meijer, M.C. van Beek, W.H. Rensen, J.W. Bijlsma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives In rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA.

Methods In 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28

Results At the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, p

Conclusions In this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA.

Original language	English
Pages (from-to)	511-518
Number of pages	8
Journal	Annals of the Rheumatic Diseases
Volume	75
Issue number	3
Early online date	9 Oct 2015
DOIs	https://doi.org/10.1136/annrheumdis-2015-207315
Publication status	Published - Mar 2016

Keywords

ULTRASOUND SCORE
SYNOVITIS
ULTRASONOGRAPHY
RELIABILITY
JOINTS
REMISSION
FINGER

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Cite this

van Onna, M., ten Cate, D. F., Tsoi, K. L., Meier, A. J., Jacobs, J. W., Westgeest, A. A., Meijer, P. B., van Beek, M. C., Rensen, W. H., & Bijlsma, J. W. (2016). Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique. Annals of the Rheumatic Diseases, 75(3), 511-518. https://doi.org/10.1136/annrheumdis-2015-207315

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title = "Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique",

abstract = "Objectives In rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA.Methods In 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28Results At the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, pConclusions In this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA.",

keywords = "ULTRASOUND SCORE, SYNOVITIS, ULTRASONOGRAPHY, RELIABILITY, JOINTS, REMISSION, FINGER",

author = "{van Onna}, M. and {ten Cate}, D.F. and K.L. Tsoi and A.J. Meier and J.W. Jacobs and A.A. Westgeest and P.B. Meijer and {van Beek}, M.C. and W.H. Rensen and J.W. Bijlsma",

year = "2016",

month = mar,

doi = "10.1136/annrheumdis-2015-207315",

language = "English",

volume = "75",

pages = "511--518",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

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van Onna, M, ten Cate, DF, Tsoi, KL, Meier, AJ, Jacobs, JW, Westgeest, AA, Meijer, PB, van Beek, MC, Rensen, WH & Bijlsma, JW 2016, 'Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique', Annals of the Rheumatic Diseases, vol. 75, no. 3, pp. 511-518. https://doi.org/10.1136/annrheumdis-2015-207315

TY - JOUR

T1 - Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique

AU - van Onna, M.

AU - ten Cate, D.F.

AU - Tsoi, K.L.

AU - Meier, A.J.

AU - Jacobs, J.W.

AU - Westgeest, A.A.

AU - Meijer, P.B.

AU - van Beek, M.C.

AU - Rensen, W.H.

AU - Bijlsma, J.W.

PY - 2016/3

Y1 - 2016/3

N2 - Objectives In rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA.Methods In 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28Results At the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, pConclusions In this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA.

AB - Objectives In rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA.Methods In 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28Results At the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, pConclusions In this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA.

KW - ULTRASOUND SCORE

KW - SYNOVITIS

KW - ULTRASONOGRAPHY

KW - RELIABILITY

KW - JOINTS

KW - REMISSION

KW - FINGER

U2 - 10.1136/annrheumdis-2015-207315

DO - 10.1136/annrheumdis-2015-207315

M3 - Article

SN - 0003-4967

VL - 75

SP - 511

EP - 518

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 3

ER -