Ascorbic acid serum levels are reduced in patients with hematological malignancies

Mirelle Huijskens; Will Wodzig; Mateusz Walczak; Wilfred Germeraad; Gerardus Bos

doi:10.1016/j.rinim.2016.01.001

Ascorbic acid serum levels are reduced in patients with hematological malignancies

Mirelle Huijskens, Will Wodzig, Mateusz Walczak, Wilfred Germeraad^*, Gerardus Bos

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

Original language	English
Pages (from-to)	8-10
Journal	Results in Immunology
Volume	6
DOIs	https://doi.org/10.1016/j.rinim.2016.01.001
Publication status	Published - 2016

Access to Document

10.1016/j.rinim.2016.01.001Licence: CC BY-NC-ND

Cite this

@article{f67d38948e044a7285ff61a9a4f9840d,

title = "Ascorbic acid serum levels are reduced in patients with hematological malignancies",

abstract = "In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.",

author = "Mirelle Huijskens and Will Wodzig and Mateusz Walczak and Wilfred Germeraad and Gerardus Bos",

year = "2016",

doi = "10.1016/j.rinim.2016.01.001",

language = "English",

volume = "6",

pages = "8--10",

journal = "Results in Immunology",

issn = "2211-2839",

publisher = "Elsevier",

}

TY - JOUR

T1 - Ascorbic acid serum levels are reduced in patients with hematological malignancies

AU - Huijskens, Mirelle

AU - Wodzig, Will

AU - Walczak, Mateusz

AU - Germeraad, Wilfred

AU - Bos, Gerardus

PY - 2016

Y1 - 2016

N2 - In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

AB - In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

U2 - 10.1016/j.rinim.2016.01.001

DO - 10.1016/j.rinim.2016.01.001

M3 - Article

C2 - 27014565

SN - 2211-2839

VL - 6

SP - 8

EP - 10

JO - Results in Immunology

JF - Results in Immunology

ER -