Aortic elongation part II: the risk of acute type A aortic dissection

Samuel Heuts; Bouke P. Adriaans; Suzanne Gerretsen; Ehsan Natour; Rein Vos; Emile C. Cheriex; Harry J. G. M. Crijns; Joachim E. Wildberger; Jos G. Maessen; Simon Schalla; Peyman Sardari Nia

doi:10.1136/heartjnl-2017-312867

Aortic elongation part II: the risk of acute type A aortic dissection

Samuel Heuts^*, Bouke P. Adriaans, Suzanne Gerretsen, Ehsan Natour, Rein Vos, Emile C. Cheriex, Harry J. G. M. Crijns, Joachim E. Wildberger, Jos G. Maessen, Simon Schalla, Peyman Sardari Nia

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives Prophylactic surgery for prevention of acute type A aortic dissection (ATAAD) is reserved for patients with an ascending aortic aneurysm =55 mm. Identification of additional risk predictors is warranted since over 70% of patients presenting with ATAAD have a non-dilated aorta or an aneurysm that would not have met the diameter criterion for preventative surgery. Aim of the study was to evaluate ascending aortic elongation as a risk factor for ATAAD and to compare aortic lengths between ATAAD patients and healthy controls.

Methods Aortic lengths and diameters of ATAAD patients were measured on three-dimensional modelled computed tomography and adjusted to predissection dimensions in this cross-sectional single-centre study. Logistic regression was used to evaluate the relation between ATAAD and aortic dimensions. Lengths of different aortic segments were compared with a healthy control group using propensity score matching.

Results Two-hundred and fifty patients were included in the study (ATAAD, n=40; controls, n=210). Ascending aortic length and diameter proved to be independent predictors for ATAAD (OR=5.3, CI 2.5 to 11.4, p

Conclusions Ascending aortic length could serve as an independent predictor for ATAA D. Future studies addressing indications for prophylactic surgery should also investigate aortic length.

Original language	English
Pages (from-to)	1778-1782
Number of pages	5
Journal	Heart
Volume	104
Issue number	21
DOIs	https://doi.org/10.1136/heartjnl-2017-312867
Publication status	Published - Nov 2018

Keywords

THORACIC AORTA
INTERNATIONAL REGISTRY
ANEURYSM
ASSOCIATION
GUIDELINES
MANAGEMENT
DIAGNOSIS
GEOMETRY
SOCIETY
DISEASE

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10.1136/heartjnl-2017-312867

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Cite this

@article{f2dd340567a54bf3a92a9a5494164c46,

title = "Aortic elongation part II: the risk of acute type A aortic dissection",

abstract = "Objectives Prophylactic surgery for prevention of acute type A aortic dissection (ATAAD) is reserved for patients with an ascending aortic aneurysm =55 mm. Identification of additional risk predictors is warranted since over 70% of patients presenting with ATAAD have a non-dilated aorta or an aneurysm that would not have met the diameter criterion for preventative surgery. Aim of the study was to evaluate ascending aortic elongation as a risk factor for ATAAD and to compare aortic lengths between ATAAD patients and healthy controls.Methods Aortic lengths and diameters of ATAAD patients were measured on three-dimensional modelled computed tomography and adjusted to predissection dimensions in this cross-sectional single-centre study. Logistic regression was used to evaluate the relation between ATAAD and aortic dimensions. Lengths of different aortic segments were compared with a healthy control group using propensity score matching.Results Two-hundred and fifty patients were included in the study (ATAAD, n=40; controls, n=210). Ascending aortic length and diameter proved to be independent predictors for ATAAD (OR=5.3, CI 2.5 to 11.4, pConclusions Ascending aortic length could serve as an independent predictor for ATAA D. Future studies addressing indications for prophylactic surgery should also investigate aortic length.",

keywords = "THORACIC AORTA, INTERNATIONAL REGISTRY, ANEURYSM, ASSOCIATION, GUIDELINES, MANAGEMENT, DIAGNOSIS, GEOMETRY, SOCIETY, DISEASE",

author = "Samuel Heuts and Adriaans, {Bouke P.} and Suzanne Gerretsen and Ehsan Natour and Rein Vos and Cheriex, {Emile C.} and Crijns, {Harry J. G. M.} and Wildberger, {Joachim E.} and Maessen, {Jos G.} and Simon Schalla and {Sardari Nia}, Peyman",

year = "2018",

month = nov,

doi = "10.1136/heartjnl-2017-312867",

language = "English",

volume = "104",

pages = "1778--1782",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "21",

}

TY - JOUR

T1 - Aortic elongation part II

T2 - the risk of acute type A aortic dissection

AU - Heuts, Samuel

AU - Adriaans, Bouke P.

AU - Gerretsen, Suzanne

AU - Natour, Ehsan

AU - Vos, Rein

AU - Cheriex, Emile C.

AU - Crijns, Harry J. G. M.

AU - Wildberger, Joachim E.

AU - Maessen, Jos G.

AU - Schalla, Simon

AU - Sardari Nia, Peyman

PY - 2018/11

Y1 - 2018/11

N2 - Objectives Prophylactic surgery for prevention of acute type A aortic dissection (ATAAD) is reserved for patients with an ascending aortic aneurysm =55 mm. Identification of additional risk predictors is warranted since over 70% of patients presenting with ATAAD have a non-dilated aorta or an aneurysm that would not have met the diameter criterion for preventative surgery. Aim of the study was to evaluate ascending aortic elongation as a risk factor for ATAAD and to compare aortic lengths between ATAAD patients and healthy controls.Methods Aortic lengths and diameters of ATAAD patients were measured on three-dimensional modelled computed tomography and adjusted to predissection dimensions in this cross-sectional single-centre study. Logistic regression was used to evaluate the relation between ATAAD and aortic dimensions. Lengths of different aortic segments were compared with a healthy control group using propensity score matching.Results Two-hundred and fifty patients were included in the study (ATAAD, n=40; controls, n=210). Ascending aortic length and diameter proved to be independent predictors for ATAAD (OR=5.3, CI 2.5 to 11.4, pConclusions Ascending aortic length could serve as an independent predictor for ATAA D. Future studies addressing indications for prophylactic surgery should also investigate aortic length.

AB - Objectives Prophylactic surgery for prevention of acute type A aortic dissection (ATAAD) is reserved for patients with an ascending aortic aneurysm =55 mm. Identification of additional risk predictors is warranted since over 70% of patients presenting with ATAAD have a non-dilated aorta or an aneurysm that would not have met the diameter criterion for preventative surgery. Aim of the study was to evaluate ascending aortic elongation as a risk factor for ATAAD and to compare aortic lengths between ATAAD patients and healthy controls.Methods Aortic lengths and diameters of ATAAD patients were measured on three-dimensional modelled computed tomography and adjusted to predissection dimensions in this cross-sectional single-centre study. Logistic regression was used to evaluate the relation between ATAAD and aortic dimensions. Lengths of different aortic segments were compared with a healthy control group using propensity score matching.Results Two-hundred and fifty patients were included in the study (ATAAD, n=40; controls, n=210). Ascending aortic length and diameter proved to be independent predictors for ATAAD (OR=5.3, CI 2.5 to 11.4, pConclusions Ascending aortic length could serve as an independent predictor for ATAA D. Future studies addressing indications for prophylactic surgery should also investigate aortic length.

KW - THORACIC AORTA

KW - INTERNATIONAL REGISTRY

KW - ANEURYSM

KW - ASSOCIATION

KW - GUIDELINES

KW - MANAGEMENT

KW - DIAGNOSIS

KW - GEOMETRY

KW - SOCIETY

KW - DISEASE

U2 - 10.1136/heartjnl-2017-312867

DO - 10.1136/heartjnl-2017-312867

M3 - Article

SN - 1355-6037

VL - 104

SP - 1778

EP - 1782

JO - Heart

JF - Heart

IS - 21

ER -