TY - JOUR
T1 - Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies
AU - Kitahara, Cari M.
AU - McCullough, Marjorie L.
AU - Franceschi, Silvia
AU - Rinaldi, Sabina
AU - Wolk, Alicja
AU - Neta, Gila
AU - Adami, Hans Olov
AU - Anderson, Kristin
AU - Andreotti, Gabriella
AU - Freeman, Laura E. Beane
AU - Bernstein, Leslie
AU - Buring, Julie E.
AU - Clavel-Chapelon, Francoise
AU - De Roo, Lisa A.
AU - Gao, Yu-Tang
AU - Gaziano, J. Michael
AU - Giles, Graham G.
AU - Hakansson, Niclas
AU - Horn-Ross, Pamela L.
AU - Kirsh, Vicki A.
AU - Linet, Martha S.
AU - Maclnnis, Robert J.
AU - Orsini, Nicola
AU - Park, Yikyung
AU - Patel, Alpa V.
AU - Purdue, Mark P.
AU - Riboli, Elio
AU - Robien, Kimberly
AU - Rohan, Thomas
AU - Sandler, Dale P.
AU - Schairer, Catherine
AU - Schneider, Arthur B.
AU - Sesso, Howard D.
AU - Shu, Xiao-Ou
AU - Singh, Pramil N.
AU - van den Brandt, Piet A.
AU - Ward, Elizabeth
AU - Weiderpass, Elisabete
AU - White, Emily
AU - Xiang, Yong-Bing
AU - Zeleniuch-Jacquotte, Anne
AU - Zheng, Wei
AU - Hartge, Patricia
AU - de Gonzalez, Amy Berrington
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5cm)=1.07 [1.04-1.10], BMI (per 5kg/m(2))=1.06 [1.02-1.10], waist circumference (per 5cm)=1.03 [1.01-1.05], young-adult BMI (per 5kg/m(2))=1.13 [1.02-1.25], and adulthood BMI gain (per 5kg/m(2))=1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p=0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.
AB - Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5cm)=1.07 [1.04-1.10], BMI (per 5kg/m(2))=1.06 [1.02-1.10], waist circumference (per 5cm)=1.03 [1.01-1.05], young-adult BMI (per 5kg/m(2))=1.13 [1.02-1.25], and adulthood BMI gain (per 5kg/m(2))=1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p=0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.
U2 - 10.1089/thy.2015.0319
DO - 10.1089/thy.2015.0319
M3 - Article
C2 - 26756356
SN - 1050-7256
VL - 26
SP - 306
EP - 318
JO - Thyroid
JF - Thyroid
IS - 2
ER -