Abstract
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.
Original language | English |
---|---|
Pages (from-to) | 216-227 |
Number of pages | 12 |
Journal | European journal of heart failure |
Volume | 20 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2018 |
Keywords
- Heart failure with preserved ejection fraction
- Animal models
- Experimental evaluation
- Molecular biology
- Myocardial function
- VENTRICULAR DIASTOLIC DYSFUNCTION
- NONCARDIAC COMORBIDITIES
- EXERCISE INTOLERANCE
- PULMONARY-HYPERTENSION
- CARDIAC STRUCTURE
- CLINICAL-TRIALS
- OLDER-ADULTS
- PRESSURE
- STRESS
- TITIN