TY - JOUR
T1 - Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage
T2 - The Maastricht Study
AU - Martens, Remy J. H.
AU - van der Berg, Julianne D.
AU - Stehouwer, Coen D. A.
AU - Henry, Ronald M. A.
AU - Bosma, Hans
AU - Dagnelie, Pieter C.
AU - van Dongen, Martien C. J. M.
AU - Eussen, Simone J. P. M.
AU - Schram, Miranda T.
AU - Sep, Simone J. S.
AU - van der Kellen, Carla J. H.
AU - Schaper, Nicolaas C.
AU - Savelberg, Hans H. C. M.
AU - van der Sande, Frank M.
AU - Kroon, Abraham A.
AU - Kooman, Jeroen P.
AU - Koster, Annemarie
PY - 2018/4/4
Y1 - 2018/4/4
N2 - BackgroundChronic kidney disease, which is defined as having a reduced kidney function (estimated glomerular filtration rate (eGFR)) and/or signs of kidney damage (albuminuria), is highly prevalent in Western society and is associated with adverse health outcomes, such as cardiovascular disease. This warrants a search for risk factors of lower eGFR and higher albuminuria. Physical activity and sedentary behavior may be such risk factors.ObjectiveTo examine associations of physical activity (total, high, low), sedentary time and sedentary behavior patterns (breaks, prolonged bouts, average bout duration) with eGFR and albuminuria.MethodsWe examined these associations in 2,258 participants of the Maastricht Study (average age 60.1 +/- 8.1 years; 51.3% men), who wore an accelerometer 24h/day on 7 consecutive days. Associations with continuous eGFR and categories of urinary albumin excretion (UAE; = 30 mg/24h) were evaluated with linear regression analyses and multinomial logistic regression analyses, respectively.ResultsAfter adjustment for potential confounders, each extra hour of total physical activity was associated with a more favorable kidney function (beta(eGFR) = 2.30 (95%CI= 1.46; 3.14)), whereas each extra hour of sedentary behavior was associated with a more adverse kidney function (beta(eGFR) =-0.71 (-1.08;-0.35)). Also, compared to individuals with the lowest levels of total physical activity, individuals with the highest levels had less kidney damage (OR15-= 30mg/24h = 0.84 (0.53; 1.35). An extra hour of sedentary behavior was associated with more kidney damage (OR15-= 30 mg/24h =1.10 (0.99; 1.22)). Further, a highly sedentary pattern was associated with a more adverse kidney function, but no association was seen with kidney damage.ConclusionsPhysical activity and sedentary behavior were associated with kidney function and kidney damage. Additionally, sedentary behavior patterns were associated with kidney function. Causal studies are required to examine whether this indeed implicates that prevention strategies should focus not only on increasing physical activity, but on reducing sedentary behavior as well.
AB - BackgroundChronic kidney disease, which is defined as having a reduced kidney function (estimated glomerular filtration rate (eGFR)) and/or signs of kidney damage (albuminuria), is highly prevalent in Western society and is associated with adverse health outcomes, such as cardiovascular disease. This warrants a search for risk factors of lower eGFR and higher albuminuria. Physical activity and sedentary behavior may be such risk factors.ObjectiveTo examine associations of physical activity (total, high, low), sedentary time and sedentary behavior patterns (breaks, prolonged bouts, average bout duration) with eGFR and albuminuria.MethodsWe examined these associations in 2,258 participants of the Maastricht Study (average age 60.1 +/- 8.1 years; 51.3% men), who wore an accelerometer 24h/day on 7 consecutive days. Associations with continuous eGFR and categories of urinary albumin excretion (UAE; = 30 mg/24h) were evaluated with linear regression analyses and multinomial logistic regression analyses, respectively.ResultsAfter adjustment for potential confounders, each extra hour of total physical activity was associated with a more favorable kidney function (beta(eGFR) = 2.30 (95%CI= 1.46; 3.14)), whereas each extra hour of sedentary behavior was associated with a more adverse kidney function (beta(eGFR) =-0.71 (-1.08;-0.35)). Also, compared to individuals with the lowest levels of total physical activity, individuals with the highest levels had less kidney damage (OR15-= 30mg/24h = 0.84 (0.53; 1.35). An extra hour of sedentary behavior was associated with more kidney damage (OR15-= 30 mg/24h =1.10 (0.99; 1.22)). Further, a highly sedentary pattern was associated with a more adverse kidney function, but no association was seen with kidney damage.ConclusionsPhysical activity and sedentary behavior were associated with kidney function and kidney damage. Additionally, sedentary behavior patterns were associated with kidney function. Causal studies are required to examine whether this indeed implicates that prevention strategies should focus not only on increasing physical activity, but on reducing sedentary behavior as well.
KW - GLOMERULAR-FILTRATION-RATE
KW - SITTING TIME
KW - CARDIOVASCULAR-DISEASE
KW - UNITED-STATES
KW - ESTIMATED GFR
KW - METAANALYSIS
KW - RISK
KW - ADULTS
KW - MICROALBUMINURIA
KW - ALBUMINURIA
U2 - 10.1371/journal.pone.0195306
DO - 10.1371/journal.pone.0195306
M3 - Article
C2 - 29617428
SN - 1932-6203
VL - 13
JO - PLOS ONE
JF - PLOS ONE
IS - 4
M1 - 0195306
ER -