Altered Cellular Metabolism Drives Trained Immunity

Yahya Sohrabi; Rinesh Godfrey; Hannes M. Findeisen

doi:10.1016/j.tem.2018.03.012

Altered Cellular Metabolism Drives Trained Immunity

Yahya Sohrabi^*, Rinesh Godfrey, Hannes M. Findeisen^*

^*Corresponding author for this work

Fysiologie

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

Original language	English
Pages (from-to)	602-605
Number of pages	5
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2018.03.012
Publication status	Published - 1 Sept 2018

Keywords

INDUCTION

Access to Document

10.1016/j.tem.2018.03.012

Cite this

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title = "Altered Cellular Metabolism Drives Trained Immunity",

abstract = "Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.",

keywords = "INDUCTION",

author = "Yahya Sohrabi and Rinesh Godfrey and Findeisen, {Hannes M.}",

year = "2018",

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AU - Godfrey, Rinesh

AU - Findeisen, Hannes M.

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N2 - Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

AB - Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

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DO - 10.1016/j.tem.2018.03.012

M3 - Editorial

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JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

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