Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies

J.E. Lee; D.J. Hunter; D. Spiegelman; H.O. Adami; D. Albanes; L. Bernstein; P.A. van den Brandt; J.E. Buring; E. Cho; A.R. Folsom; J.L. Freudenheim; E. Giovannucci; S. Graham; P.L. Horn Ross; M.F. Leitzmann; M.L. McCullough; A.B. Miller; A.S. Parker; C. Rodriguez; T.E. Rohan; A. Schatzkin; L.J. Schouten; M. Virtanen; W.C. Willett; A. Wolk; S.M. Zhang; S.A. Smith Warner

doi:10.1093/jnci/djk181

Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies

J.E. Lee^*, D.J. Hunter, D. Spiegelman, H.O. Adami, D. Albanes, L. Bernstein, P.A. van den Brandt, J.E. Buring, E. Cho, A.R. Folsom, J.L. Freudenheim, E. Giovannucci, S. Graham, P.L. Horn Ross, M.F. Leitzmann, M.L. McCullough, A.B. Miller, A.S. Parker, C. Rodriguez, T.E. RohanA. Schatzkin, L.J. Schouten, M. Virtanen, W.C. Willett, A. Wolk, S.M. Zhang, S.A. Smith Warner

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

239 Downloads (Pure)

Abstract

BACKGROUND: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. METHODS: We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. RESULTS: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). CONCLUSION: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.

Original language	English
Pages (from-to)	801-810
Journal	Journal of the National Cancer Institute
Volume	99
Issue number	10
DOIs	https://doi.org/10.1093/jnci/djk181
Publication status	Published - 1 Jan 2007

Access to Document

10.1093/jnci/djk181

Full TextFinal published version, 162 KB

Cite this

Lee, J. E., Hunter, D. J., Spiegelman, D., Adami, H. O., Albanes, D., Bernstein, L., van den Brandt, P. A., Buring, J. E., Cho, E., Folsom, A. R., Freudenheim, J. L., Giovannucci, E., Graham, S., Horn Ross, P. L., Leitzmann, M. F., McCullough, M. L., Miller, A. B., Parker, A. S., Rodriguez, C., ... Smith Warner, S. A. (2007). Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies. Journal of the National Cancer Institute, 99(10), 801-810. https://doi.org/10.1093/jnci/djk181

@article{2bd9461ee0a14498942e95d294e410e2,

title = "Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies",

abstract = "BACKGROUND: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. METHODS: We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. RESULTS: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). CONCLUSION: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.",

author = "J.E. Lee and D.J. Hunter and D. Spiegelman and H.O. Adami and D. Albanes and L. Bernstein and {van den Brandt}, P.A. and J.E. Buring and E. Cho and A.R. Folsom and J.L. Freudenheim and E. Giovannucci and S. Graham and {Horn Ross}, P.L. and M.F. Leitzmann and M.L. McCullough and A.B. Miller and A.S. Parker and C. Rodriguez and T.E. Rohan and A. Schatzkin and L.J. Schouten and M. Virtanen and W.C. Willett and A. Wolk and S.M. Zhang and {Smith Warner}, S.A.",

year = "2007",

month = jan,

day = "1",

doi = "10.1093/jnci/djk181",

language = "English",

volume = "99",

pages = "801--810",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "10",

}

Lee, JE, Hunter, DJ, Spiegelman, D, Adami, HO, Albanes, D, Bernstein, L, van den Brandt, PA, Buring, JE, Cho, E, Folsom, AR, Freudenheim, JL, Giovannucci, E, Graham, S, Horn Ross, PL, Leitzmann, MF, McCullough, ML, Miller, AB, Parker, AS, Rodriguez, C, Rohan, TE, Schatzkin, A, Schouten, LJ, Virtanen, M, Willett, WC, Wolk, A, Zhang, SM & Smith Warner, SA 2007, 'Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies', Journal of the National Cancer Institute, vol. 99, no. 10, pp. 801-810. https://doi.org/10.1093/jnci/djk181

TY - JOUR

T1 - Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies

AU - Lee, J.E.

AU - Hunter, D.J.

AU - Spiegelman, D.

AU - Adami, H.O.

AU - Albanes, D.

AU - Bernstein, L.

AU - van den Brandt, P.A.

AU - Buring, J.E.

AU - Cho, E.

AU - Folsom, A.R.

AU - Freudenheim, J.L.

AU - Giovannucci, E.

AU - Graham, S.

AU - Horn Ross, P.L.

AU - Leitzmann, M.F.

AU - McCullough, M.L.

AU - Miller, A.B.

AU - Parker, A.S.

AU - Rodriguez, C.

AU - Rohan, T.E.

AU - Schatzkin, A.

AU - Schouten, L.J.

AU - Virtanen, M.

AU - Willett, W.C.

AU - Wolk, A.

AU - Zhang, S.M.

AU - Smith Warner, S.A.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - BACKGROUND: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. METHODS: We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. RESULTS: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). CONCLUSION: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.

AB - BACKGROUND: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. METHODS: We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. RESULTS: A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). CONCLUSION: Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.

U2 - 10.1093/jnci/djk181

DO - 10.1093/jnci/djk181

M3 - Article

SN - 0027-8874

VL - 99

SP - 801

EP - 810

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 10

ER -