TY - JOUR
T1 - Adiposity, Muscle Mass, and Muscle Strength in Relation to Functional Decline in Older Persons
AU - Schaap, Laura A.
AU - Koster, Annemarie
AU - Visser, Marjolein
PY - 2013/2/4
Y1 - 2013/2/4
N2 - Aging is associated with changes in body composition and muscle strength. This review aimed to determine the relation between different body composition measures and muscle strength measures and functional decline in older men and women. By use of relevant databases (PubMed, Embase, and CINAHL) and keywords in a search from 1976 to April 2012, 50 articles were reviewed that met the inclusion criteria (written in English, a prospective, longitudinal design, involving older persons aged 65 years or more, and at least one of the measures that follow: body mass index (BMI), waist circumference, waist/hip ratio, midarm circumference, fat mass, muscle fat infiltration, muscle mass, or strength as independent variables and a measure of functional decline as outcome measure). Meta-analyses were performed and revealed that BMI >= 30 and low muscle strength were associated with functional decline (pooled odds ratio (OR) = 1.60, 95% confidence interval (Cl): 1.43, 1.80, for BMI >= 30 and OR = 1.86, 95% Cl: 1.32, 2.64, for muscle strength). Low muscle mass was not significantly associated with functional decline (pooled OR = 1.19, 95% Cl: 0.98, 1.45). Future intervention research should focus on positive changes in body composition to prevent onset or worsening of functional decline in old age.
AB - Aging is associated with changes in body composition and muscle strength. This review aimed to determine the relation between different body composition measures and muscle strength measures and functional decline in older men and women. By use of relevant databases (PubMed, Embase, and CINAHL) and keywords in a search from 1976 to April 2012, 50 articles were reviewed that met the inclusion criteria (written in English, a prospective, longitudinal design, involving older persons aged 65 years or more, and at least one of the measures that follow: body mass index (BMI), waist circumference, waist/hip ratio, midarm circumference, fat mass, muscle fat infiltration, muscle mass, or strength as independent variables and a measure of functional decline as outcome measure). Meta-analyses were performed and revealed that BMI >= 30 and low muscle strength were associated with functional decline (pooled odds ratio (OR) = 1.60, 95% confidence interval (Cl): 1.43, 1.80, for BMI >= 30 and OR = 1.86, 95% Cl: 1.32, 2.64, for muscle strength). Low muscle mass was not significantly associated with functional decline (pooled OR = 1.19, 95% Cl: 0.98, 1.45). Future intervention research should focus on positive changes in body composition to prevent onset or worsening of functional decline in old age.
KW - adiposity
KW - aging
KW - body composition
KW - muscles
KW - muscle strength
KW - obesity
U2 - 10.1093/epirev/mxs006
DO - 10.1093/epirev/mxs006
M3 - Article
SN - 0193-936X
VL - 35
SP - 51
EP - 65
JO - Epidemiologic Reviews
JF - Epidemiologic Reviews
ER -