Abstract
Aims: Exercise combined with adipose tissue lipolytic inhibition augments intramuscular lipid and glycogen use in type 2 diabetes patients. The present study investigates the impact of adipose tissue lipolytic inhibition during exercise on subsequent postprandial glycemic control in type 2 diabetes patients.Methods: Fourteen male type 2 diabetes patients (age 652 years, HbA(1c) 6.70.1% (50 +/- 2mmol/mol)) participated in a double-blind placebo-controlled randomized cross-over study in which subjects performed endurance-type exercise after being administered 250mg of a nicotinic acid analogue (acipimox; ACP) or a placebo (PLA). A control experiment was included in which no exercise was performed (CON).Results: Sixty minutes of endurance-type exercise (at 45% W-peak) did not significantly lower circulating plasma glucose and insulin excursions in PLA when compared with CON (P=.300). Acipimox administration strongly reduced circulating plasma FFA concentrations during exercise (P<.001). Circulating plasma glucose and insulin excursions were substantially lower during 7.5h of recovery from exercise (i.e. postprandial) in ACP when compared with either CON (P=.041 and P=.002, respectively) or PLA (P=.009 and P=.001, respectively).Conclusions: Collectively, exercise with adipose tissue lipolytic inhibition reduces postprandial blood glucose and insulin excursions and, as such, further improves glycemic control in male type 2 diabetes patients.
Original language | English |
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Pages (from-to) | 1245-1254 |
Number of pages | 10 |
Journal | European Journal of Sport Science |
Volume | 18 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
Keywords
- Exercise
- metabolism
- physiology
- sedentary living
- HUMAN SKELETAL-MUSCLE
- INSULIN-RESISTANCE
- GLUCOSE-METABOLISM
- GLYCEMIC CONTROL
- NICOTINIC-ACID
- ALL-CAUSE
- SENSITIVITY
- MELLITUS
- TRIACYLGLYCEROL
- HYPERGLYCEMIA