Abstract
We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.
Original language | English |
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Pages (from-to) | 91-92 |
Number of pages | 2 |
Journal | Therapeutic Drug Monitoring |
Volume | 39 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Acute Kidney Injury
- Anti-HIV Agents
- Benzoxazines
- Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- Emtricitabine
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Tenofovir
- Case Reports
- Journal Article