TY - JOUR
T1 - Absence of 18 F‐fluorodeoxyglucose uptake using Positron Emission Tomography/Computed Tomography in Madelung's disease: A case report
AU - Moonen, Michiel P. B.
AU - Nascimento, Emmani B. M.
AU - van Kroonenburgh, Marinus J. P. G.
AU - Brandjes, Dees
AU - van Marken Lichtenbelt, Wouter D.
N1 - Funding Information:
The authors would also like to thank Nicole Bouvy and Karin Sanders, Paul van Dijk and Gert Schaart for obtaining and processing of the biopsy material.
Publisher Copyright:
© 2019 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation
PY - 2019/6
Y1 - 2019/6
N2 - Madelung's disease is characterized by the manifestation of multiple ectopic lipomas, usually found in the cervical-thoracic region, however, clinical manifestation may vary among patients. It has been postulated that lipomas associated with Madelung's disease are linked to brown adipose tissue (BAT) due to the presence of uncoupling protein 1 (UCP1). Therefore, we here investigated whether BAT activity is present in a patient with Madelung's disease. F-18-fluorodeoxyglucose (F-18-FDG) uptake using PET/CT after a cooling procedure was measured together with body temperature and energy expenditure. Finally, adipose tissue biopsies were taken from the lipomas for gene expression analysis and histology. F-18-FDG uptake was not detected after the cooling procedure in the lipomas. Furthermore, adipose tissue biopsies derived from the lipomas did not express UCP1. We thus conclude that cold-stimulated BAT activity was not detected in lipomas associated with Madelung's disease. Additional research in other patients is needed to unravel the role of dysfunctional BAT in Madelung's disease.
AB - Madelung's disease is characterized by the manifestation of multiple ectopic lipomas, usually found in the cervical-thoracic region, however, clinical manifestation may vary among patients. It has been postulated that lipomas associated with Madelung's disease are linked to brown adipose tissue (BAT) due to the presence of uncoupling protein 1 (UCP1). Therefore, we here investigated whether BAT activity is present in a patient with Madelung's disease. F-18-fluorodeoxyglucose (F-18-FDG) uptake using PET/CT after a cooling procedure was measured together with body temperature and energy expenditure. Finally, adipose tissue biopsies were taken from the lipomas for gene expression analysis and histology. F-18-FDG uptake was not detected after the cooling procedure in the lipomas. Furthermore, adipose tissue biopsies derived from the lipomas did not express UCP1. We thus conclude that cold-stimulated BAT activity was not detected in lipomas associated with Madelung's disease. Additional research in other patients is needed to unravel the role of dysfunctional BAT in Madelung's disease.
KW - brown adipose tissue
KW - Madelung's disease
KW - MULTIPLE SYMMETRIC LIPOMATOSIS
KW - BROWN ADIPOSE-TISSUE
U2 - 10.1111/cob.12302
DO - 10.1111/cob.12302
M3 - Article
C2 - 30815996
SN - 1758-8103
VL - 9
SP - 1
EP - 4
JO - Clinical Obesity
JF - Clinical Obesity
IS - 3
M1 - 12302
ER -