TY - JOUR
T1 - A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men
T2 - A randomized controlled trial
AU - Bell, Kirsten E.
AU - Snijders, Tim
AU - Zulyniak, Michael
AU - Kumbhare, Dinesh
AU - Parise, Gianni
AU - Chabowski, Adrian
AU - Phillips, Stuart M.
PY - 2017/7/18
Y1 - 2017/7/18
N2 - Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 +/- 1 years [mean +/- SEM]; BMI: 28.5 +/- 1.5 kg/m(2)) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Sigma 1RM, SUPP: +14 +/- 4 kg, CON: +3 +/- 2 kg, P <0.001) and lean mass (LBM, + 1.2 +/- 0.3 kg, CON: -0.1 +/- 0.2 kg, P <0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Sigma upper body 1RM: 119 +/- 4 vs. 109 +/- 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training.
AB - Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 +/- 1 years [mean +/- SEM]; BMI: 28.5 +/- 1.5 kg/m(2)) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Sigma 1RM, SUPP: +14 +/- 4 kg, CON: +3 +/- 2 kg, P <0.001) and lean mass (LBM, + 1.2 +/- 0.3 kg, CON: -0.1 +/- 0.2 kg, P <0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Sigma upper body 1RM: 119 +/- 4 vs. 109 +/- 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training.
KW - VITAMIN-D SUPPLEMENTATION
KW - IMPROVES MUSCULAR PERFORMANCE
KW - FAT-FREE MASS
KW - SKELETAL-MUSCLE
KW - CREATINE SUPPLEMENTATION
KW - RESISTANCE EXERCISE
KW - ELDERLY-MEN
KW - WEIGHT-LOSS
KW - ADULTS
KW - METAANALYSIS
U2 - 10.1371/journal.pone.0181387
DO - 10.1371/journal.pone.0181387
M3 - Article
SN - 1932-6203
VL - 12
JO - PLOS ONE
JF - PLOS ONE
IS - 7
M1 - e0181387
ER -