@article{3b55cad32ce9476c89001cf7f2c99d4a,
title = "A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry",
abstract = "Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.",
keywords = "BAEYER-VILLIGER OXIDATION, CHEMICALS, CONDENSATION, ENVIRONMENTAL ASSESSMENT, GREEN CHEMISTRY, ISOPHORONE, METRICS, MONOOXYGENASES, SCALE, SUSTAINABILITY, biocatalysis, life cycle assessment, oxidative chemistry, process metrics, sustainable chemistry",
author = "Marie Delgove and Achille-B. Laurent and John Woodley and {de Wildeman}, Stefaan and Katrien Bernaerts and {van der Meer}, Yvonne",
note = "Funding Information: The research for this work has received funding from the European Union (EU) project ROBOX (grant agreement No. 635734) under the EU{\textquoteright}s Horizon 2020 Programme Research and Innovation actions H2020-LEIT BIO-2014-1. The views and opinions expressed in this article are only those of the authors, and do not necessarily reflect those of the European Union Research Agency. The European Union is not liable for any use that may be made of the information contained herein. Funding Information: The research for this work has received funding from the European Union (EU) project ROBOX (grant agreement No. 635734) under the EU′s Horizon 2020 Programme Research and Innovation actions H2020-LEIT BIO-2014-1. The views and opinions expressed in this article are only those of the authors, and do not necessarily reflect those of the European Union Research Agency. The European Union is not liable for any use that may be made of the information contained herein. Publisher Copyright: {\textcopyright} 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",
year = "2019",
month = apr,
day = "5",
doi = "10.1002/cssc.201900007",
language = "English",
volume = "12",
pages = "1349--1360",
journal = "Chemsuschem",
issn = "1864-5631",
publisher = "Wiley-VCH Verlag",
number = "7",
}