Abstract
Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. Methods: Six-week-old C57Bl/6 mice were fed a high-fat diet for 12 weeks and scheduled for OAGB or sham operation. Mice were observed for 2 weeks after the operation, and weight and metabolic condition were monitored. Results: Six mice were used to adapt the surgical technique. Afterwards, another 7 mice were scheduled for OAGB without further complications. The newly established OAGB procedure resulted in significant weight loss and improvement of glucose metabolism 2 weeks after the operation. Conclusions: The operation presented here is an easy-to-learn and physiologic mouse model of OAGB that can be used for further studies in mice. (c) 2018 S. Karger AG, Basel
Original language | English |
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Pages (from-to) | 320-328 |
Number of pages | 9 |
Journal | European Surgical Research |
Volume | 59 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - Nov 2018 |
Keywords
- One anastomosis gastric bypass
- Mini-gastric bypass
- Mouse model
- Bariatric surgery
- INTENSIVE MEDICAL THERAPY
- ROUX-EN-Y
- BARIATRIC SURGERY
- GLUCOSE-HOMEOSTASIS
- SLEEVE GASTRECTOMY
- WEIGHT-LOSS
- OBESITY